声源性癫痫与松果体

Audiogenic seizures and the pineal gland.

作者信息

de Azevedo B A, Fontana Júnior P

机构信息

Oswaldo Cruz Institute, Manguinhos, Rio de Janeiro, Brazil.

出版信息

Biol Psychiatry. 1988 Apr 1;23(7):734-40. doi: 10.1016/0006-3223(88)90058-3.

DOI:10.1016/0006-3223(88)90058-3

PMID:3130899

Abstract

The effects of sound stimulation (electric bell, 110 dB) on the pineal glands of adult female rats were studied. Two types of animals were selected: audiogenic (Adg) and nonaudiogenic (Nadg). Unlike the Nadg rats, Adg rats exhibited tonic-clonic seizures in response to stimulation. In Adg rats, after a single seizure, all pinealocyte nuclei were pyknotic and the characteristic lobular organization of the pineal was markedly disrupted, indicating intense glandular stress; however, neither serotonin levels nor its biosynthesis were significantly altered. These results suggest a physiopathological relationship between audiogenic seizures and the pineal gland.

摘要

研究了声音刺激（电铃，110分贝）对成年雌性大鼠松果体的影响。选取了两种类型的动物：听源性发作（Adg）和非听源性发作（Nadg）。与Nadg大鼠不同，Adg大鼠在受到刺激时会出现强直阵挛性发作。在Adg大鼠中，单次发作后，所有松果体细胞的细胞核都发生了固缩，松果体特有的小叶结构明显被破坏，表明腺体受到强烈应激；然而，血清素水平及其生物合成均未发生显著改变。这些结果提示听源性发作与松果体之间存在生理病理关系。