Manvi Sujaya, Mahajan Vikram K, Mehta Karaninder S, Yadav R S, Bhushan Satya, Chauhan Pushpinder S
Resident, Dr. R.P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh.
Prof., Dr. R.P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh; *Corresponding Author.
J Assoc Physicians India. 2019 Apr;67(4):29-32.
Hyperhomocystienemia is a plausible common link between psoriasis and associated co-morbidities.
To assess and compare serum homocystiene levels in 160(M:F 94:66) patients aged 18-70 years with chronic plaque psoriasis of varying severity with or without metabolic syndrome, cardiovascular and thyroid disorders and controls. The 155 controls (M:F 97:58) were healthy volunteers aged between 18 and 66 years.
Overall, 123 (76.9%) psoriasis patients with or without co-morbidities and 87 (56.1%) controls had elevated serum homocystiene levels; 23.48±14.37 and 18.74±12.59 (mean±SD) µmol/L, respectively. Eighty-one (58%) patients had associated co-morbidities with mean serum homocystiene levels of 22.65±13.70 µmol/L.The difference between psoriasis patients with or without comorbidities and controls was statistically significant.
Hyperhomocystienemia in psoriasis patients with or without comorbidities versus healthy controls suggests its possible dysregulation in psoriasis. The significance of hyperhomocystienemia as an independent risk factor for cardiovascular or other comorbidities in psoriasis patients remains tenuous at best. Well-designed studies will perhaps resolve this issue.
高同型半胱氨酸血症可能是银屑病及其相关合并症之间的共同联系。
评估并比较160例（男:女为94:66）年龄在18至70岁之间、患有不同严重程度慢性斑块状银屑病且伴有或不伴有代谢综合征、心血管疾病和甲状腺疾病的患者与对照组的血清同型半胱氨酸水平。155名对照组（男:女为97:58）为年龄在18至66岁之间的健康志愿者。
总体而言，123例（76.9%）伴有或不伴有合并症的银屑病患者以及87例（56.1%）对照组的血清同型半胱氨酸水平升高；分别为23.48±14.37和18.74±12.59（均值±标准差）μmol/L。8位（58%）患者伴有合并症，其血清同型半胱氨酸平均水平为22.65±13.70μmol/L。伴有或不伴有合并症的银屑病患者与对照组之间的差异具有统计学意义。
伴有或不伴有合并症的银屑病患者与健康对照组相比存在高同型半胱氨酸血症，提示其在银屑病中可能存在调节异常。高同型半胱氨酸血症作为银屑病患者心血管疾病或其他合并症独立危险因素的意义充其量仍不明确。精心设计的研究或许能解决这一问题。
