Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital & The Royal College of Surgeons in Ireland, Dublin, Ireland.
Royal College of Surgeons Ireland, Dublin, Ireland.
Clin Transplant. 2019 Oct;33(10):e13669. doi: 10.1111/ctr.13669. Epub 2019 Sep 30.
Solid organ transplant recipients are at increased risk of cancer compared to the general population. To date, this risk in Ireland has not been investigated. We conducted a national registry study of cancer incidence following solid organ transplantation.
National centers for solid organ transplantation supplied their respective registry databases to cross-reference with episodes of malignancy from the National Cancer Registry Ireland (NCRI) between 1994 and 2014. Standardized incidence of cancer post-transplant was compared to the general population by means of standardized incidence ratios (SIRs), and between solid organ transplant types by incidence rate ratios.
A total of 3346 solid organ transplant recipients were included in this study. Kidney transplant recipients constituted the majority of participants (71.2%), followed by liver (16.8%), heart (6.4%), and lung (5.6%) transplants. The most common cancers within the composite of all transplant recipients included the following (SIR [95% CI]): squamous and basal cell carcinoma (20.05 [17.97, 22.31] and 7.16 [6.43, 7.96], respectively), non-Hodgkin lymphoma (6.23 [4.26, 8.59]), and renal cell carcinoma (3.36 [1.96, 5.38]).
This study reports the incidence of cancer following solid organ transplantation in Ireland. These results have significant national policy implications for surveillance, and early diagnosis in this patient group.
与普通人群相比，实体器官移植受者罹患癌症的风险增加。迄今为止，爱尔兰尚未对此风险进行研究。我们对爱尔兰全国范围内实体器官移植后癌症发病率进行了一项基于注册的研究。
各实体器官移植中心向爱尔兰国家癌症登记处（NCRI）提供了各自的注册数据库，以对 1994 年至 2014 年期间 NCRI 中恶性肿瘤的发病情况进行交叉参考。通过标准化发病比（SIR）比较移植后癌症的发病率与普通人群，通过发病率比比较各实体器官移植类型之间的癌症发病率。
本研究共纳入 3346 例实体器官移植受者。肾移植受者占多数（71.2%），其次为肝（16.8%）、心脏（6.4%）和肺（5.6%）移植。所有移植受者中最常见的癌症（复合癌）包括以下几种（SIR [95%CI]）：鳞状细胞癌和基底细胞癌（20.05 [17.97, 22.31] 和 7.16 [6.43, 7.96]）、非霍奇金淋巴瘤（6.23 [4.26, 8.59]）和肾细胞癌（3.36 [1.96, 5.38]）。
本研究报告了爱尔兰实体器官移植后癌症的发病率。这些结果对该患者群体的监测和早期诊断具有重要的国家政策意义。
