Di Gregorio Luisa Maria, Zambrotta Elisa, Di Guardo Federica, Gulino Ferdinando Antonio, Musmeci Giulia, Capriglione Stella, Angioli Roberto, Palumbo Marco
Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.
Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.Electronic Address:
Int J Fertil Steril. 2019 Oct;13(3):190-195. doi: 10.22074/ijfs.2019.5614. Epub 2019 Jul 14.
The aim of this study was to evaluate the impact of body mass index (BMI) and lipid profile on reproductive outcomes of women undergoing intracytoplasmic sperm injection (ICSI) cycles.
This retrospective observational study was conducted in the Center of Human Reproductive Physiopathology of University of Catania between April 2017 and March 2018 and enrolled 114 couples undergoing ICSI. Levels of total cholesterol, low-density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c) and triglycerides were determinate and, according to the BMI, samples were divided into the following groups: group A (BMI: 18.5-24.9 kg/m); group B (BMI: 25-29.9 kg/m); and group C (BMI >30 kg/m). BMI and lipid profile associations with the number of oocytes and embryos retrieved, the oocytes and embryo quality, the fertilization rate as well as the percentage of miscarriages and pregnancies, were assessed. The statistical analysis was performed using Shapiro-Wilk test, analysis of variance (ANOVA) and Kruskal -Wallis method.
Fertilization and pregnancy rates were lower in women with BMI>30 than in women with BMI: 25-29.9 and BMI: 18.5-24.9, despite the not altered levels of lipoprotein.
Our results demonstrated that an excess of adipose tissue in women undergoing ICSI was not directly related with altered biochemical lipid values. However, overweight and obese patients showed poor fertilization and pregnancy rate despite the not altered values of lipoprotein.
本研究旨在评估体重指数（BMI）和血脂水平对接受卵胞浆内单精子注射（ICSI）周期的女性生殖结局的影响。
本回顾性观察研究于2017年4月至2018年3月在卡塔尼亚大学人类生殖生理病理学中心进行，纳入了114对接受ICSI的夫妇。测定总胆固醇、低密度脂蛋白胆固醇（LDL-c）、高密度脂蛋白胆固醇（HDL-c）和甘油三酯水平，并根据BMI将样本分为以下几组：A组（BMI：18.5-24.9kg/m）；B组（BMI：25-29.9kg/m）；C组（BMI>30kg/m）。评估BMI和血脂水平与获取的卵母细胞和胚胎数量、卵母细胞和胚胎质量、受精率以及流产和妊娠百分比之间的关联。使用Shapiro-Wilk检验、方差分析（ANOVA）和Kruskal-Wallis方法进行统计分析。
BMI>30的女性的受精率和妊娠率低于BMI为25-29.9和BMI为18.5-24.9的女性，尽管脂蛋白水平未改变。
我们的结果表明，接受ICSI的女性体内脂肪组织过多与生化血脂值改变无直接关系。然而，超重和肥胖患者尽管脂蛋白值未改变，但受精率和妊娠率较低。
