肥胖会影响生育能力低下、有排卵的女性自然受孕的几率。
Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women.
作者信息
van der Steeg Jan Willem, Steures Pieternel, Eijkemans Marinus J C, Habbema J Dik F, Hompes Peter G A, Burggraaff Jan M, Oosterhuis G Jur E, Bossuyt Patrick M M, van der Veen Fulco, Mol Ben W J
机构信息
Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, The Netherlands.
出版信息
Hum Reprod. 2008 Feb;23(2):324-8. doi: 10.1093/humrep/dem371. Epub 2007 Dec 11.
BACKGROUND
Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women.
METHODS
We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint.
RESULTS
The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m(2). Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase [hazard ratio: 0.96 (95% CI 0.91-0.99)].
CONCLUSIONS
These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women.
背景
肥胖在全球女性中呈快速上升趋势。肥胖是因无排卵导致生育力低下的已知风险因素，但肥胖是否也会影响排卵正常的不孕女性的自然受孕几率尚不清楚。
方法
我们评估了肥胖对一个前瞻性纳入的由3029对连续不孕夫妇组成的队列中自然受孕几率的影响。女性必须排卵正常且至少有一侧输卵管通畅，而男性精液分析必须正常。12个月内自然持续妊娠的时间为主要终点。
结果
体重指数（BMI）超过29kg/m²时，自然受孕概率呈线性下降。校正可能的相关因素后，BMI每增加1kg/m²，高BMI女性的妊娠率降低4%[风险比：0.96（95%可信区间0.91 - 0.99）]。
结论
这些结果表明，肥胖与排卵正常的不孕女性较低的妊娠率相关。
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