Electrochimie et Synthèse Organique, Université Paris Est , ICMPE, (UMR 7182), CNRS, UPEC , 2-8 rue Henri Dunant, F-94320 Thiais , France.
Org Lett. 2019 Aug 2;21(15):6135-6139. doi: 10.1021/acs.orglett.9b02291. Epub 2019 Jul 16.
Galat reactions between aldehydes and substituted malonic acids half oxyester were found to be efficiently catalyzed by morpholine in refluxing toluene. This transformation allows the stereoselective synthesis of diverse α,β-disubstituted acrylates in moderate to good yields. This method constitutes an attractive alternative to existing methods in terms of scope and eco-compatibility.
在回流的甲苯中，用吗啉可以有效地催化醛和取代的丙二酸半酯之间的加合物反应。这种转化允许在中等至良好的收率下立体选择性地合成各种α，β-二取代丙烯酸酯。就范围和生态相容性而言，该方法是现有方法的一种有吸引力的替代方法。
