Department of Radiology, Naval Medical Center San Diego, 34800 Bob Wilson Dr, Ste 204, San Diego, CA 92134.
Present address: Department of Radiology, Naval Health Clinic Cherry Point, Havelock, NC 28532.
AJR Am J Roentgenol. 2019 Nov;213(5):1170-1173. doi: 10.2214/AJR.19.21400. Epub 2019 Jul 16.
The purpose of this study was to evaluate the effects of clinical 3-T MRI during pregnancy on fetal growth and neonatal hearing in neonates at low risk of congenital hearing impairment or of brain or chromosomal abnormalities. This single-center retrospective case-control study included consecutively born healthy neonates exposed in utero to 3-T MR during MRI for maternal or fetal indications and born between January 2008 and March 2015. Each exposed neonate was randomly matched 1:2 by birth date to healthy control neonates who had not been exposed to MR. Infant birth weights were compared by unpaired test. Hearing impairment between groups was compared by Fisher exact test. There was no significant difference in mean birth weight between the MR-exposed (3398 g) and control (3510 g) neonates ( = 0.06). There was no significant difference in prevalence of hearing impairment ( = 0.55) between the MR-exposed (0% [0/81]) and control (1.8% [3/162]) groups. This study showed no adverse effects with regard to neonatal hearing or fetal growth in healthy neonates who were variably exposed to 3-T MR in utero during MRI for various clinical maternal or fetal indications at any gestational age.
本研究旨在评估孕妇接受临床 3-T MRI 检查对先天性听力障碍、脑部或染色体异常低危新生儿的胎儿生长和新生儿听力的影响。这是一项单中心回顾性病例对照研究，纳入了 2008 年 1 月至 2015 年 3 月期间，因母体或胎儿指征接受 3-T MRI 检查而宫内暴露于 MRI 的连续出生的健康新生儿。每个暴露的新生儿均按出生日期随机匹配 1:2 例未暴露于 MRI 的健康对照新生儿。通过独立样本 t 检验比较婴儿的出生体重。通过 Fisher 确切概率法比较两组间听力障碍的发生率。MR 暴露组（3398g）与对照组（3510g）新生儿的平均出生体重无显著差异（ = 0.06）。MR 暴露组（0%[0/81]）与对照组（1.8%[3/162]）的听力障碍发生率无显著差异（ = 0.55）。本研究表明，在各种临床母体或胎儿指征下，在不同的胎龄接受 3-T MRI 检查的健康新生儿，其听力或胎儿生长未受不良影响。
