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克拉霉素治疗儿童牙源性脓肿分枝杆菌感染的安全性和耐受性。

Safety and Tolerability of Clofazimine in a Cohort of Children With Odontogenic Mycobacterium abscessus Infection.

机构信息

Division of Infectious Diseases, Children's Hospital of Orange County, Orange, California.

Division of Pharmacy Services, Children's Hospital of Orange County, Orange, California.

出版信息

J Pediatric Infect Dis Soc. 2020 Sep 17;9(4):483-485. doi: 10.1093/jpids/piz049.

DOI:10.1093/jpids/piz049
PMID:31310313
Abstract

Mycobacterium abscessus infections can be challenging to treat. Clofazimine has excellent in vitro activity against M abscessus, but reports of its use, particularly in children, have been limited. In this study, clofazimine was given to 27 children during an outbreak of odontogenic mycobacterial infections and seemed to be well tolerated as part of a multidrug regimen.

摘要

脓肿分枝杆菌感染的治疗具有挑战性。氯法齐明对脓肿分枝杆菌具有极好的体外活性，但有关其使用的报告，特别是在儿童中的报告，十分有限。在这项研究中，在一次牙源性分枝杆菌感染暴发期间，氯法齐明被用于 27 名儿童，作为多药方案的一部分，它似乎具有良好的耐受性。

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