通过环氧氰醇衍生物与 CpTiI 的分子内还原环化反应，用乙酰氧基马苏佩林酮全合成（±）-马苏佩林 A 和 B
Total Synthesis of (±)-Marsupellins A and B via Acetoxymarsupellone Using an Intramolecular Reductive Cyclization of Epoxycyanohydrin Derivative with CpTiI.
机构信息
Graduate School of Pharmaceutical Sciences , Meiji Pharmaceutical University , 2-522-1 Noshio , Kiyose , Tokyo 204-8588 , Japan.
出版信息
Org Lett. 2019 Aug 2;21(15):6054-6057. doi: 10.1021/acs.orglett.9b02207. Epub 2019 Jul 16.
PMID:31310558
Abstract
The first total synthesis of C3- and C9-oxidized -longipinane-type sesquiterpenoids containing acetoxymarsupellone, marsupellins A and B, has been accomplished. This unique core common to C3- and C9-oxidized -longipinane-type sesquiterpenoids was constructed via a new intramolecular reductive cyclization reaction of an epoxycyanohydrin derivative using CpTiI.
摘要
首次完成了含有乙酰氧基马鲁皮酮、马鲁皮林 A 和 B 的 C3-和 C9-氧化 -longipinane 型倍半萜的全合成。C3-和 C9-氧化 -longipinane 型倍半萜共有的这一独特核心是通过使用 CpTiI 的环氧化氰醇衍生物的新型分子内还原环化反应构建的。
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