Xiangya Stomatological Hospital, Central South University, Changsha, China.
Xiangya School of Stomatology, Central South University, Changsha, China.
J Oral Pathol Med. 2020 Apr;49(4):294-304. doi: 10.1111/jop.12924. Epub 2019 Jul 16.
Oral submucous fibrosis (OSF) is a chronic, insidious, and progressive oral mucosal disease that affects entire oral cavity and sometimes pharynx. This oral potentially malignant disorder has a high rate of malignant transformation (7%-30%) to oral squamous cell carcinoma (OSCC), posing global problems for public health. Due to enormous efforts dedicated to this disease in the past decades, there have been significant advances in identification of its etiology and pathogenesis as well as development of corresponding therapeutic approaches, in spite of several challenges. This study reviewed the existing literature concerning OSF in Asian countries, encompassing its etiology, histopathology, pathogenesis, clinical manifestations, diagnosis and differential diagnosis, and treatments. For improving treatment of OSF, the multifactorial etiology analysis, incorporation of effective molecular pathways, cytokines and cells for mechanism illustration, and integration of multidisciplinary modalities were also expounded to guide future research and clinical practice.
口腔黏膜下纤维性变（OSF）是一种慢性、隐匿性、进行性的口腔黏膜疾病，影响整个口腔，有时还会影响咽部。这种口腔潜在的恶性疾病具有很高的恶性转化（7%-30%）为口腔鳞状细胞癌（OSCC）的风险，对全球公共健康构成了问题。尽管存在一些挑战，但由于过去几十年来对这种疾病的巨大努力，在确定其病因和发病机制以及开发相应的治疗方法方面取得了重大进展。本研究综述了亚洲国家有关 OSF 的现有文献，包括其病因、组织病理学、发病机制、临床表现、诊断和鉴别诊断以及治疗。为了改善 OSF 的治疗效果，还阐述了多因素病因分析、纳入有效的分子途径、细胞因子和细胞以阐明机制，以及整合多学科模式，以指导未来的研究和临床实践。
