探讨 FTO rs9939609 基因型、禁食和餐后食欲相关激素与健康男性和女性的食欲感知之间的关联。

Exploration of associations between the FTO rs9939609 genotype, fasting and postprandial appetite-related hormones and perceived appetite in healthy men and women.

机构信息

National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom; University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester, United Kingdom.

National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.

出版信息

Appetite. 2019 Nov 1;142:104368. doi: 10.1016/j.appet.2019.104368. Epub 2019 Jul 13.

DOI:10.1016/j.appet.2019.104368

PMID:31310836

Abstract

BACKGROUND

The fat mass and obesity-associated gene (FTO) rs9939609 A-allele has been associated with obesity risk. Although the exact mechanisms involved remain unknown, the FTO rs9939609 A-allele has been associated with an impaired postprandial suppression of appetite.

OBJECTIVES

To explore the influence of FTO rs9939609 genotype on fasting and postprandial appetite-related hormones and perceived appetite in a heterogeneous sample of men and women.

DESIGN

112 healthy men and women aged 18-50-years-old completed three laboratory visits for the assessment of FTO rs9939609 genotype, body composition, aerobic fitness, resting metabolic rate, visceral adipose tissue, liver fat, fasting leptin, and fasting and postprandial acylated ghrelin, total PYY, insulin, glucose and perceived appetite. Participants wore accelerometers for seven consecutive days for the assessment of physical activity and sedentary behaviour. Multivariable general linear models quantified differences between FTO rs9939609 groups for fasting and postprandial appetite outcomes, with and without the addition of a priori selected physiological and behavioural covariates. Sex-specific univariable Pearson's correlation coefficients were quantified between the appetite-related outcomes and individual characteristics.

RESULTS

95% confidence intervals for mean differences between FTO rs9939609 groups overlapped zero in unadjusted and adjusted general linear models for all fasting (P ≥ 0.28) and postprandial (P ≥ 0.19) appetite-related outcomes. Eta values for explained variance attributable to FTO rs9939609 were <5% for all outcomes. An exploratory correlation matrix indicated that associations between fasting and postprandial acylated ghrelin, total PYY and general or abdominal adiposity were also small (r = -0.23 to 0.15, P ≥ 0.09). Fasting leptin, glucose and insulin and postprandial insulin concentrations were associated with adiposity outcomes (r = 0.29 to 0.81, P ≤ 0.033).

CONCLUSIONS

Associations between the FTO rs9939609 genotype and fasting or postprandial appetite-related outcomes were weak in healthy men and women.

摘要

背景

肥胖相关基因（FTO）rs9939609 的 A 等位基因与肥胖风险有关。尽管涉及的确切机制尚不清楚，但 FTO rs9939609 的 A 等位基因与餐后食欲抑制受损有关。

目的

在男性和女性的异质样本中，探索 FTO rs9939609 基因型对禁食和餐后食欲相关激素及食欲感知的影响。

设计

112 名年龄在 18-50 岁的健康男性和女性完成了三次实验室访视，以评估 FTO rs9939609 基因型、身体成分、有氧适能、静息代谢率、内脏脂肪组织、肝脏脂肪、空腹瘦素和空腹及餐后酰化 ghrelin、总 PYY、胰岛素、血糖和食欲感知。参与者佩戴加速度计连续七天评估身体活动和久坐行为。多变量一般线性模型量化了 FTO rs9939609 组间禁食和餐后食欲结果的差异，并在有或没有先验选择的生理和行为协变量的情况下进行了分析。使用 sex-specific univariable Pearson's 相关系数量化了食欲相关结果与个体特征之间的关系。

结果

在未调整和调整后的一般线性模型中，FTO rs9939609 组间所有空腹（P≥0.28）和餐后（P≥0.19）食欲相关结果的均值差异的 95%置信区间均与零重叠。FTO rs9939609 解释的方差百分比值均<5%。探索性相关矩阵表明，空腹和餐后酰化 ghrelin、总 PYY 与一般或腹部脂肪量之间的关联也较小（r=-0.23 至 0.15，P≥0.09）。空腹瘦素、血糖和胰岛素以及餐后胰岛素浓度与脂肪量结果相关（r=0.29 至 0.81，P≤0.033）。