Shigemasa C, Abe K, Taniguchi S, Mitani Y, Ueta Y, Urabe K, Adachi T, Tanaka T, Yoshida A, Mashiba H
First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Endocrinol Jpn. 1987 Dec;34(6):821-9. doi: 10.1507/endocrj1954.34.821.
Serum total thyroxine (T4), total triiodothyronine (T3), T4-binding globulin (TBG), free T4(FT4) and free T3(FT3) concentrations and the T3-uptake(T3-U) value were estimated in 11 patients with subacute thyroiditis, and compared with the same parameters in 11 patients with Graves' disease, whose serum T4 concentrations were similar to the former group. Seven patients with subacute thyroiditis, who were treated with dicrofenac sodium alone, were investigated as to the sequential changes in serum parameters during their clinical courses. The mean serum T3-U value and FT4, T3 and FT3 concentrations in patients with subacute thyroiditis were increased, but all were significantly lower than those in patients with Graves' disease (p less than 0.01, p less than 0.001, p less than 0.001 and p less than 0.001, respectively). Three patients with subacute thyroiditis, who showed shorter duration of symptoms than 10 days, had serum TBG excess. Thus the mean (+/- SD) serum TBG concentration (26.5 +/- 8.4 micrograms/ml) was significantly higher than that (18.3 +/- 2.9 micrograms/ml) in patients with Graves' disease (p less than 0.02). The ratios of serum T3 to T4 and FT3 to FT4 in patients with subacute thyroiditis were also significantly lower than those in patients with Graves' disease (p less than 0.001 and p less than 0.001, respectively). The serum FT4 in 7 patients treated with dicrofenac sodium alone decreased to the normal range after 3 to 8 weeks from the onset of the illness. In 3 patients with TBG excess and one patient (TBG; 29.0 micrograms/ml), serum TBG declined in consequence of the serum FT4 normalization.(ABSTRACT TRUNCATED AT 250 WORDS)
对11例亚急性甲状腺炎患者的血清总甲状腺素（T4）、总三碘甲状腺原氨酸（T3）、T4结合球蛋白（TBG）、游离T4（FT4）和游离T3（FT3）浓度以及T3摄取（T3-U）值进行了测定，并与11例血清T4浓度与前一组相似的格雷夫斯病患者的相同参数进行了比较。对7例仅用双氯芬酸钠治疗的亚急性甲状腺炎患者，研究了其临床过程中血清参数的连续变化。亚急性甲状腺炎患者的平均血清T3-U值以及FT4、T3和FT3浓度均升高，但均显著低于格雷夫斯病患者（分别为p<0.01、p<0.001、p<0.001和p<0.001）。3例症状持续时间短于10天的亚急性甲状腺炎患者存在血清TBG过量。因此，其平均（±标准差）血清TBG浓度（26.5±8.4微克/毫升）显著高于格雷夫斯病患者（18.3±2.9微克/毫升）（p<0.02）。亚急性甲状腺炎患者血清T3与T4以及FT3与FT4的比值也显著低于格雷夫斯病患者（分别为p<0.001和p<0.001）。7例仅用双氯芬酸钠治疗的患者，血清FT4在发病后3至8周降至正常范围。在3例TBG过量患者和1例患者（TBG；29.0微克/毫升）中，血清TBG因血清FT4正常化而下降。（摘要截断于250字）
