Yang Zifei, Wu Xianmin, Chen Xiaoyun, Huang Yideng, Fang Lian, Li Xiaofei, Zhang Yue, Jia Minghui
Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , PR China.
Department of Otolaryngology-Head and Neck Surgery, Shandong ENT Hospital Affiliated to Shandong University , Jinan , PR China.
Acta Otolaryngol. 2019 Oct;139(10):833-836. doi: 10.1080/00016489.2019.1637541. Epub 2019 Jul 16.
Acellular dermal allograft (AlloDerm) and cartilage perichondrium are two common materials used for repair of tympanic membrane perforations (TMPs). To date, comparative evaluations of their efficacy have rarely been reported. To compare anatomical and audiological outcomes between AlloDerm and cartilage perichondrium in type I tympanoplasty. A total of 61 patients of TMP were studied. In total, 27 patients (Group 1) underwent AlloDerm myringoplasty, and the remaining 34 patients (Group 2) underwent perichondrium myringoplasty. Operating time, closure rate and hearing gain were compared between Groups 1 and 2. Successful closure rates at 6-month follow-up were 88.9% (Group 1) and 82.4% (group 2). The average improvement of air-bone gap (ABG) was 13.5 ± 11.8 dB for Group 1 and 13.1 ± 13.1 dB for Group 2. The difference in between preoperative and 6 months postoperative ABG values was statistically significant ( < .001). Success rates and improvement of hearing level were similar for the AlloDerm (Group 1) and the cartilage perichondrium (Group 2) groups. However, AlloDerm requires shorter operative time and avoids the incisions in the harvest of allografts. Our results suggest that AlloDerm can be recommended as an attractive alternative to cartilage grafts.
脱细胞真皮同种异体移植物（AlloDerm）和软骨膜是用于修复鼓膜穿孔（TMP）的两种常见材料。迄今为止，很少有关于它们疗效的比较评估报道。为了比较AlloDerm和软骨膜在I型鼓室成形术中的解剖学和听力学结果。共研究了61例TMP患者。其中，27例患者（第1组）接受了AlloDerm鼓膜成形术，其余34例患者（第2组组组）接受了软骨膜鼓膜成形术。比较了第1组和第2组之间的手术时间、闭合率和听力增益。6个月随访时的成功闭合率在第1组为88.9%，在第2组为82.4%。第1组气骨导间距（ABG）的平均改善为13.5±11.8dB，第2组为13.1±13.1dB。术前和术后6个月ABG值之间的差异具有统计学意义（<0.001）。AlloDerm组（第1组）和软骨膜组（第2组）的成功率和听力水平改善相似。然而，AlloDerm所需手术时间更短，且避免了同种异体移植物获取时的切口。我们的结果表明，AlloDerm可被推荐为软骨移植的一种有吸引力的替代方案。
