1 Health Management Center, Shandong University Qilu Hospital, Jinan, China.
2 Radiotherapy Department, Shandong University Qilu Hospital, Jinan, China.
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819864313. doi: 10.1177/1533033819864313.
Reactive oxygen species play a vital role in cell survival by regulating physiological metabolism and signal transduction of cells. The imbalance of oxidant and antioxidant states induces oxidative stress within a cell. Redox regulation and oxidative stress are closely related to survival and proliferation of stem cells, cancer cells, and cancer stem cells. Peroxiredoxin 4, a typical endoplasmic reticulum-resident 2-Cys antioxidant of peroxiredoxins, can fine-tune hydrogen peroxide catabolism which affects cell survival by affecting redox balance, oxidative protein folding, and regulation of hydrogen peroxide signaling. Recent studies revealed the overexpression of peroxiredoxin 4 in several kinds of cancers, such as breast cancer, prostate cancer, ovarian cancer, colorectal cancer, and lung cancer. And it has been demonstrated that peroxiredoxin 4 causally contributes to tumorigenesis, therapeutic resistance, metastasis, and recurrence of tumors. In this article, the characteristics of peroxiredoxin 4 in physiological functions and the cancer-related research progress of mammalian peroxiredoxin 4 is reviewed. We believe that peroxiredoxin 4 has the potential of serving as a novel target for multiple cancers.
活性氧在细胞存活中起着至关重要的作用，可调节细胞的生理代谢和信号转导。氧化还原状态的失衡会导致细胞内的氧化应激。氧化还原调节和氧化应激与干细胞、癌细胞和癌症干细胞的存活和增殖密切相关。过氧化物酶 4 是过氧化物酶家族中典型的内质网驻留 2-Cys 抗氧化剂，它可以通过影响氧化还原平衡、氧化蛋白折叠和调节过氧化氢信号来微调过氧化氢的分解代谢，从而影响细胞存活。最近的研究表明，过氧化物酶 4 在多种癌症中过度表达，如乳腺癌、前列腺癌、卵巢癌、结直肠癌和肺癌。并且已经证明过氧化物酶 4 导致肿瘤发生、治疗耐药、转移和肿瘤复发。本文综述了过氧化物酶 4 在生理功能方面的特征以及哺乳动物过氧化物酶 4 与癌症相关的研究进展。我们相信过氧化物酶 4 有可能成为多种癌症的新靶点。
