Guan Xin, Ruan Yiyin, Che Xiaoxia, Feng Weiwei
Department of Obstetrics & Gynecology, Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Obstetrics & Gynecology, Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Free Radic Biol Med. 2024 Jan;210:120-129. doi: 10.1016/j.freeradbiomed.2023.11.009. Epub 2023 Nov 15.
Tumour cells often display an active metabolic profile, leading to the intracellular accumulation of reactive oxygen species. As a member of the peroxidase family, peroxiredoxin 1 (PRDX1) functions generally in protecting against cell damage caused by H2O2. Additionally, PRDX1 plays a role as a molecular chaperone in various malignant tumours, exhibiting either tumour-promoting or tumour-suppressing effects. Currently, PRDX1-targeting drugs have demonstrated in vitro anticancer effects, indicating the potential of PRDX1 as a molecular target. Here we discussed the diverse functions of PRDX1 in tumour biology and provided a comprehensive analysis of the therapeutic potential of targeting PRDX1 signalling across various types of cancer.
肿瘤细胞通常表现出活跃的代谢特征，导致细胞内活性氧的积累。作为过氧化物酶家族的一员，过氧化物还原酶1（PRDX1）通常发挥作用，保护细胞免受H2O2引起的损伤。此外，PRDX1在各种恶性肿瘤中作为分子伴侣发挥作用，表现出促肿瘤或抑肿瘤作用。目前，靶向PRDX1的药物已显示出体外抗癌效果，表明PRDX1作为分子靶点的潜力。在此，我们讨论了PRDX1在肿瘤生物学中的多种功能，并对靶向PRDX1信号通路在各种癌症类型中的治疗潜力进行了全面分析。
