固态 NMR 技术在淀粉样纤维结构和动力学研究 20 年的进展。
Two decades of progress in structural and dynamic studies of amyloids by solid-state NMR.
机构信息
Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA.
出版信息
J Magn Reson. 2019 Sep;306:42-47. doi: 10.1016/j.jmr.2019.07.015. Epub 2019 Jul 9.
Abstract
In this perspective article I briefly highlight the rapid progress made over the past two decades in atomic level structural and dynamic studies of amyloids, which are representative of non-crystalline biomacromolecular assemblies, by magic-angle spinning solid-state NMR spectroscopy. Given new and continuing developments in solid-state NMR instrumentation and methodology, ongoing research in this area promises to contribute to an improved understanding of amyloid structure, polymorphism, interactions, assembly mechanisms, and biological function and toxicity.
摘要
在这篇观点文章中，我简要地强调了过去二十年来，通过魔角旋转固态 NMR 光谱学对淀粉样物（代表非晶态生物大分子组装体）的原子级结构和动态研究方面取得的快速进展。鉴于固态 NMR 仪器和方法的新的和持续的发展，该领域的持续研究有望有助于提高对淀粉样结构、多态性、相互作用、组装机制以及生物学功能和毒性的理解。
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