嗜碱性粒细胞白血病与胃酸和胃蛋白酶分泌过多

Basophilic leukemia and the hypersecretion of gastric acid and pepsin.

作者信息

Anderson W, Helman C A, Hirschowitz B I

机构信息

Division of Gastroenterology, University of Alabama at Birmingham.

出版信息

Gastroenterology. 1988 Jul;95(1):195-8. doi: 10.1016/0016-5085(88)90311-3.

DOI:10.1016/0016-5085(88)90311-3

PMID:3131179

Abstract

A 48-yr-old man with chronic myelogenous leukemia and basophilia developed a duodenal ulcer and hemorrhage. Gastric analysis revealed basal hyper-secretion of acid (33.1 mEq/h) and pepsin (44.5 x 10(-4) peptic units/h). Blood, serum, and urine histamine was elevated and serum gastrin was normal. Although acid output was markedly suppressed with ranitidine (50 mg i.v.), pepsin secretion was only inhibited 63% and had returned to basal levels by the sixth hour. Maximal acid output does not suggest a trophic effect of histamine in this patient. The previously reported cases of basophilic leukemia and gastric hypersecretion or duodenal ulcer disease are reviewed.

摘要

一名48岁患有慢性粒细胞白血病和嗜碱性粒细胞增多症的男性发生了十二指肠溃疡并出血。胃液分析显示基础胃酸分泌过多（33.1毫当量/小时）和胃蛋白酶分泌过多（44.5×10⁻⁴ 消化单位/小时）。血液、血清和尿液中的组胺升高，而血清胃泌素正常。尽管雷尼替丁（静脉注射50毫克）可显著抑制胃酸分泌，但胃蛋白酶分泌仅被抑制63%，并在第六小时恢复到基础水平。最大胃酸分泌量并不提示组胺对该患者有营养作用。对先前报道的嗜碱性粒细胞白血病与胃酸分泌过多或十二指肠溃疡病的病例进行了综述。