Hirata T, Tani M, Yamagishi T, Shimazu H
Gastroenterol Jpn. 1978;13(1):28-32. doi: 10.1007/BF02774151.
Intraduodenal instillation of hypertonic glucose significantly inhibited tetragastrin-induced gastric acid and pepsin outputs in man. The secretory volume of gastric juice was markedly decreased, whereas, acid concentration remained unchanged. Pepsin concentration, on the contrary, was reduced significantly. The degree of inhibition of pepsin output, therefore, was greater than that of acid output. No significant difference in the extent of inhibition of acid or pepsin output was observed between control subjects and patients with duodenal ulcer.
十二指肠内滴注高渗葡萄糖可显著抑制人胃泌素诱导的胃酸和胃蛋白酶分泌。胃液分泌量显著减少，而胃酸浓度保持不变。相反，胃蛋白酶浓度显著降低。因此，胃蛋白酶分泌的抑制程度大于胃酸分泌的抑制程度。在对照组受试者和十二指肠溃疡患者之间，未观察到胃酸或胃蛋白酶分泌抑制程度的显著差异。
