Li Xianrui, Zhang Meng, Li Kun, Zou Feng, Wang Yufeng, Wu Xin, Zhang Hongxing
School of Psychology, Xinxiang Medical University, Xinxiang, China.
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Front Psychiatry. 2019 Jul 1;10:465. doi: 10.3389/fpsyt.2019.00465. eCollection 2019.
Highly anxious individuals often show excessive emotional arousal, somatic arousal, and characteristics of mental illness. Previous researches have extensively investigated the emotional and cognitive biases of individuals with high anxiety, but overlooked the spontaneous brain activity and functional connections associated with somatic arousal. In this study, we investigated the relationship between state anxiety and the spontaneous brain activity of the somatosensory cortex in a non-clinical healthy population with state anxiety. Furthermore, we also explored the functional connections of the somatosensory cortex. We found that state anxiety was positively correlated with the amplitude of low-frequency fluctuations (ALFFs) of somatic related brain regions, including the right postcentral gyrus (somatosensory cortex) and the right precentral gyrus (somatic motor cortex). Furthermore, we found that state anxiety was positively correlated with the connections between the postcentral gyrus and the left cerebellum gyrus, whereas state anxiety was negatively correlated with the connectivity between the postcentral gyrus and brain regions including the left inferior frontal cortex and left medial superior frontal cortex. These results revealed the association between the anxious individuals' body-loop and state anxiety in a healthy population, which revealed the importance of somatic brain regions in anxiety symptoms and provided a new perspective on anxiety for further study.
高度焦虑的个体常常表现出过度的情绪唤醒、躯体唤醒以及精神疾病的特征。以往的研究广泛调查了高焦虑个体的情绪和认知偏差，但忽视了与躯体唤醒相关的自发脑活动和功能连接。在本研究中，我们在一个有状态焦虑的非临床健康人群中，研究了状态焦虑与躯体感觉皮层自发脑活动之间的关系。此外，我们还探讨了躯体感觉皮层的功能连接。我们发现，状态焦虑与躯体相关脑区的低频振幅（ALFFs）呈正相关，这些脑区包括右侧中央后回（躯体感觉皮层）和右侧中央前回（躯体运动皮层）。此外，我们发现状态焦虑与中央后回和左侧小脑回之间的连接呈正相关，而状态焦虑与中央后回和包括左侧额下回及左侧额上内侧回在内的脑区之间的连接性呈负相关。这些结果揭示了健康人群中焦虑个体的身体环路与状态焦虑之间的关联，揭示了躯体脑区在焦虑症状中的重要性，并为焦虑研究提供了一个新的视角。
