He Xin-Wei, Zhao Rong, Li Ge-Fei, Zheng Bo, Wu Yi-Lan, Shi Yan-Hui, Liu Yi-Sheng, Zhuang Mei-Ting, Yin Jia-Wen, Cui Guo-Hong, Liu Jian-Ren
Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Neurol. 2019 Jul 2;10:696. doi: 10.3389/fneur.2019.00696. eCollection 2019.
There have been few studies about the association between intracranial carotid artery calcification (ICAC) and acute ischemic stroke (AIS) prognosis after intravenous thrombolysis (IVT). We aimed to analyze the association between ICAC and prognosis (including symptomatic intracranial hemorrhage (sICH), functional outcome and death) of AIS patients treated with IVT. In this retrospective study, we consecutively included 232 AIS patients treated with IVT between April 2012 and December 2018. ICAC was evaluated using the modified Woodcock calcification visual score on non-enhanced cranial computed tomography scans. Poor functional outcome was defined as a modified Rankin Scale score > 2 at 3 months. We found that the modified Woodcock calcification score was associated with ICH, poor outcome, and death in univariable analyses on the symptomatic side and/or bilaterally. However, after adjustment for other different covariates, the results showed no significant difference. We documented that the presence and severity of ICAC did not significantly modify the beneficial effects of rtPA treatment in AIS.
关于颅内颈动脉钙化（ICAC）与静脉溶栓（IVT）后急性缺血性卒中（AIS）预后之间的关联，相关研究较少。我们旨在分析ICAC与接受IVT治疗的AIS患者预后（包括症状性颅内出血（sICH）、功能结局和死亡）之间的关联。在这项回顾性研究中，我们连续纳入了2012年4月至2018年12月期间接受IVT治疗的232例AIS患者。通过在非增强头颅计算机断层扫描上使用改良的伍德科克钙化视觉评分来评估ICAC。功能结局不佳定义为3个月时改良Rankin量表评分>2分。我们发现，在对有症状一侧和/或双侧进行的单变量分析中，改良的伍德科克钙化评分与ICH、不良结局和死亡相关。然而，在对其他不同协变量进行调整后，结果显示无显著差异。我们记录到，ICAC的存在和严重程度并未显著改变rtPA治疗对AIS的有益效果。
