Muñoz Ospina Beatriz, Valderrama Chaparro Jaime Andrés, Arango Paredes Juan David, Castaño Pino Yor Jaggy, Navarro Andrés, Orozco Jorge Luis
Fundación Valle del Lili, Departamento de Neurología, Cra 98 #18-49, Cali 760032, Colombia.
i2t Research Group, Universidad Icesi, Cl. 18 #122-135, Cali, Colombia.
Parkinsons Dis. 2019 Jun 13;2019:5050182. doi: 10.1155/2019/5050182. eCollection 2019.
Gait alterations are hallmarks for the diagnosis and follow-up of patients with Parkinson's disease (PD). In normal conditions, age could affect gait dynamics. Although it is known that objective assessment of gait is a valuable tool for diagnosis and follow-up of patients with PD, only few studies evaluate the effect of aging on the gait pattern of patients with PD.
The purpose of this study was to assess differences in gait dynamics between PD patients and healthy subjects and to investigate the effects of aging on these differences using a low-cost RGB-D depth-sensing camera.
30 PD patients and 30 age-matched controls were recruited. Descriptive analysis was used for clinical variables, and Spearman's rank correlation was used to correlate age and gait variables. The sample was distributed in age groups; then, Mann-Whitney test was used for comparison of gait variables between groups.
PD patients exhibited prolonged swing (=0.002) and stance times ( < 0.001) and lower speed values ( < 0.001) compared to controls. This was consistent in all age groups, except for the one between 76 and 88 years old, in which the controls were slower and had longer swing and stance times. These results were statically significant for the group from 60 to 66 years.
Gait speed, swing, and stance times are useful for differentiating PD patients from controls. Quantitative gait parameters measured by an RGB-D camera can complement clinical assessment of PD patients. The analysis of these spatiotemporal variables should consider the age of the subject.
步态改变是帕金森病（PD）患者诊断和随访的标志。在正常情况下，年龄会影响步态动力学。虽然已知步态的客观评估是PD患者诊断和随访的一项有价值的工具，但只有少数研究评估了衰老对PD患者步态模式的影响。
本研究的目的是评估PD患者与健康受试者之间步态动力学的差异，并使用低成本的RGB-D深度感应相机研究衰老对这些差异的影响。
招募了30名PD患者和30名年龄匹配的对照者。对临床变量进行描述性分析，并使用Spearman等级相关性分析年龄与步态变量之间的关系。样本按年龄组分布；然后，使用Mann-Whitney检验比较组间的步态变量。
与对照组相比，PD患者的摆动时间延长（=0.002）、站立时间延长（<0.001）且速度值较低（<0.001）。在所有年龄组中均如此，但76至88岁的年龄组除外，该年龄组中对照组的速度较慢，摆动和站立时间较长。对于60至66岁的组，这些结果具有统计学意义。
步态速度、摆动时间和站立时间有助于区分PD患者与对照者。通过RGB-D相机测量的定量步态参数可以补充PD患者的临床评估。对这些时空变量的分析应考虑受试者的年龄。
