Myers Tanya R, McCarthy Natalie L, Panagiotakopoulos Lakshmi, Omer Saad B
Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Departments of Epidemiology and Global Health, Emory University, Atlanta, Georgia.
Open Forum Infect Dis. 2019 Mar 15;6(3):ofz071. doi: 10.1093/ofid/ofz071. eCollection 2019 Mar.
Guillain-Barré syndrome (GBS) is an adverse event of interest after vaccination, yet few data are available for background rates during pregnancy. We confirmed 2 cases of incident GBS and estimated an incidence of 2.8 confirmed GBS cases per million person-years (95% confidence interval, 0.5-9.3), indicating rare occurrence. Our findings will help inform safety assessments of Zika vaccines in pregnant populations.
吉兰-巴雷综合征（GBS）是疫苗接种后令人关注的不良事件，但关于孕期背景发病率的数据却很少。我们确诊了2例新发GBS病例，并估计发病率为每百万人年2.8例确诊GBS病例（95%置信区间，0.5 - 9.3），表明其发生率很低。我们的研究结果将有助于为孕期人群寨卡疫苗的安全性评估提供参考。
