定量 CMR 灌注成像与同时 O-水-PET 的比较评估。
Evaluation of quantitative CMR perfusion imaging by comparison with simultaneous O-water-PET.
机构信息
Medical Imaging Centre, Uppsala University Hospital, 75185, Uppsala, Sweden.
Department of Surgical Sciences/Radiology, Uppsala University, Uppsala, Sweden.
出版信息
J Nucl Cardiol. 2021 Aug;28(4):1252-1266. doi: 10.1007/s12350-019-01810-z. Epub 2019 Jul 16.
BACKGROUND
We assessed the quantitative accuracy of cardiac perfusion measurements using dynamic contrast-enhanced MRI with simultaneous O-water PET as reference with a fully integrated PET-MR scanner.
METHODS
15 patients underwent simultaneous DCE MRI and O-water PET scans at rest and adenosine-stress on an integrated PET-MR scanner. Correlation and agreement between MRI- and PET-based global and regional MBF values were assessed using correlation and Bland-Altman analysis.
RESULTS
Three subjects were excluded due to technical problems. Global mean (± SD) MBF values at rest and stress were 0.97 ± 0.27 and 3.19 ± 0.70 mL/g/min for MRI and 1.02 ± 0.28 and 3.13 ± 1.16 mL/g/min for PET (P = 0.66 and P = 0.81). The correlations between global and regional MRI- and PET-based MBF values were strong (r = 0.86 and r = 0.75). The biases were negligible for both global and regional MBF comparisons (0.01 and 0.00 mL/min/g for both), but the limits of agreement were wide for both global and regional MBF, with larger variability for high MBF-values.
CONCLUSION
The correlation between simultaneous MBF measurements with DCE MRI and O-water PET measured in an integrated PET-MRI was strong but the agreement was only moderate indicating that MRI-based quantitative MBF measurements is not ready for clinical introduction.
背景
我们评估了使用动态对比增强 MRI 与同步 O-水 PET 作为参考的心脏灌注测量的定量准确性，该研究使用的是完全集成的 PET-MR 扫描仪。
方法
15 例患者在集成的 PET-MR 扫描仪上进行了静息和腺苷应激状态下的 DCE MRI 和 O-水 PET 扫描。使用相关性和 Bland-Altman 分析评估 MRI 和 PET 基于全局和局部 MBF 值的相关性和一致性。
结果
由于技术问题，有 3 名受试者被排除在外。MRI 和 PET 的静息和应激时的全局平均（±SD）MBF 值分别为 0.97 ± 0.27 和 3.19 ± 0.70 mL/g/min 和 1.02 ± 0.28 和 3.13 ± 1.16 mL/g/min（P = 0.66 和 P = 0.81）。全局和局部 MRI 和 PET 基于 MBF 值的相关性很强（r = 0.86 和 r = 0.75）。对于全局和局部 MBF 比较，偏差可以忽略不计（两者均为 0.01 和 0.00 mL/min/g），但全局和局部 MBF 的一致性范围很宽，高 MBF 值的变异性更大。
结论
DCE MRI 和同步 O-水 PET 测量的 MBF 同步测量之间的相关性很强，但一致性仅为中等，表明基于 MRI 的定量 MBF 测量尚未准备好用于临床应用。
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