College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province, China.
Biomater Sci. 2019 Aug 20;7(9):3552-3565. doi: 10.1039/c9bm00580c.
Extracellular vesicles (EVs) are shed from most mammalian cells by different processes. EVs possess several distinct advantages, including excellent biocompatibility, good bio-stability and low immunogenicity. Moreover, they play significant roles in physiological and pathological processes. Challenges in EV research mainly concern highly efficient isolation, specific membrane surface engineering and further development of EV applications in biomedical fields. In this review, we summarize the recent and representative research regarding isolation, engineering and biomedical applications of EVs, which represent important research focus areas. These three aspects have not ever been systematically classified and summarized in previous reviews. Finally, we give our insights into the key issues concerning EVs and their future development for biomedical applications.
细胞外囊泡 (EVs) 通过不同的过程从大多数哺乳动物细胞中释放出来。EVs 具有几个明显的优点，包括极好的生物相容性、良好的生物稳定性和低免疫原性。此外，它们在生理和病理过程中发挥着重要作用。EV 研究的挑战主要集中在高效分离、特定的膜表面工程以及 EV 在生物医学领域应用的进一步发展上。在这篇综述中，我们总结了最近和具有代表性的关于 EV 的分离、工程和生物医学应用的研究，这些研究代表了重要的研究重点领域。这三个方面在以前的综述中从未被系统地分类和总结过。最后，我们对 EV 及其未来在生物医学应用中的发展的关键问题提出了我们的看法。
