Islam Mohammad Rashedul, Young Michael F., Wrann Christiane D.
Massachussetts General Hospital and Harvard Medical School, Charlestown, MA, USA
Exercise can improve cognitive function and the outcome of neurodegenerative diseases like Alzheimer’s disease. This effect has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Recently, we have reported a PGC-1α-FNDC5/irisin pathway that is activated by exercise in the hippocampus in mice and induces a neuroprotective gene program, including . This review will focus on FNDC5 and its secreted form “irisin,” a newly discovered myokine, its role in the nervous system and its therapeutic potential. In addition, we will briefly discuss the role of other exercise-induced myokines in positive brain effects.
运动可以改善认知功能以及诸如阿尔茨海默病等神经退行性疾病的预后。这种效应与脑源性神经营养因子（BDNF）表达的增加有关。然而，驱动这种神经营养因子升高的潜在分子机制仍不清楚。最近，我们报道了一条PGC-1α-FNDC5/鸢尾素通路，该通路在小鼠海马体中被运动激活，并诱导一个神经保护基因程序，包括…… 本综述将聚焦于FNDC5及其分泌形式“鸢尾素”，一种新发现的肌动蛋白，它在神经系统中的作用及其治疗潜力。此外，我们将简要讨论其他运动诱导的肌动蛋白在对大脑产生积极影响方面的作用。
