连续铑（II）和布朗斯台德酸催化的糖基化反应。
Glycosylation Enabled by Successive Rhodium(II) and Brønsted Acid Catalysis.
机构信息
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy , Huazhong University of Science and Technology , 13 Hangkong Road , Wuhan , Hubei 430030 , China.
出版信息
J Am Chem Soc. 2019 Jul 31;141(30):11775-11780. doi: 10.1021/jacs.9b04619. Epub 2019 Jul 19.
Herein, we reported on a highly efficient glycosylation reaction comprising two chronological meticulously designed catalytic cycles: (1) rhodium-catalyzed formation of sulfonium ylide and (2) Brønsted acid-catalyzed formation of sulfonium ion. This protocol highlighted an effective and robust tactic to prepare a glycosyl sulfonium ion from a glycosyl sulfonium ylide precursor amenable for glycosylation.
在此，我们报道了一个高效的糖基化反应，包括两个精心设计的时序催化循环：（1）铑催化形成硫叶立德，（2）布朗斯台德酸催化形成硫翁离子。该方案突出了一种有效而稳健的策略，可从糖基化硫叶立德前体制备糖基化硫翁离子，适用于糖基化反应。
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