三氟甲基取代的硫叶立德：铑催化的类卡宾对三氟甲硫醚的加成反应。
Trifluoromethyl-substituted sulfonium ylide: Rh-catalyzed carbenoid addition to trifluoromethylthioether.
作者信息
Liu Yafei, Shao Xinxin, Zhang Panpan, Lu Long, Shen Qilong
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
出版信息
Org Lett. 2015 Jun 5;17(11):2752-5. doi: 10.1021/acs.orglett.5b01170. Epub 2015 May 14.
PMID:25974253
Abstract
A highly efficient Rh-catalyzed carbenoid addition to trifluoromethylthioether for the formation of trifluoromethyl-substituted sulfonium ylide is described. The trifluoromethyl-substituted sulfonium ylide can act as an electrophilic trifluoromethylation reagent, as demonstrated by trifluoromethylation of β-ketoesters and aryl iodides.
摘要
描述了一种高效的铑催化的类卡宾加成到三氟甲硫醚以形成三氟甲基取代的硫叶立德的反应。三氟甲基取代的硫叶立德可作为亲电三氟甲基化试剂，β-酮酯和芳基碘化物的三氟甲基化反应证明了这一点。
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