Department of Clinical Sciences Karolinska Institute, Danderyd University Hospital, Stockholm, Sweden.
Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department of Moscow, Moscow, Russian Federation.
J Mot Behav. 2020;52(4):383-395. doi: 10.1080/00222895.2019.1639608. Epub 2019 Jul 17.
In this study we compared the effects of transcranial direct current stimulation (tDCS) in the subacute and chronic stages of post-stroke recovery. Anodal/sham tDCS was applied to the primary motor cortex of stroke patients in these stages of recovery in a cross-over design. The Jebsen-Taylor hand function test was employed. The repeated-measure ANOVA showed significant influence of the stimulation type and test performance time (during/after tDCS) with no overall influence of recovery stage. The interaction TYPETIMESTAGE was significant. The effect after anodal tDCS in the subacute stage was significantly higher compared to the effects in all relevant conditions including the chronic stage. Therefore, tDCS treatment in the subacute stage of recovery can be superior, at least for some patients, to treatment in the chronic stage.
在这项研究中，我们比较了经颅直流电刺激（tDCS）在中风后恢复的亚急性期和慢性期的效果。在交叉设计中，将阳极/假 tDCS 应用于这些恢复阶段的中风患者的初级运动皮层。采用了杰普森-泰勒手功能测试。重复测量方差分析显示，刺激类型和测试表现时间（tDCS 期间/之后）有显著影响，而恢复阶段没有总体影响。刺激类型时间阶段的相互作用具有统计学意义。亚急性期阳极 tDCS 的效果明显高于所有相关条件（包括慢性期）的效果。因此，至少对于一些患者来说，恢复期的亚急性期 tDCS 治疗可以优于慢性期的治疗。
