Jobin Kaiden, Smith Ashley, Campbell Christina, Schabrun Siobhan, Galarneau Jean-Michel, Schneider Kathryn J, Debert Chantel T
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Vivo Cura Health, Calgary, AB, Canada.
NeuroRehabilitation. 2025 Apr 27:10538135251325384. doi: 10.1177/10538135251325384.
ObjectiveThe objectives of this study were to evaluate functional outcomes of cervical motor control, strength and endurance following active transcranial direct current stimulation (tDCS) with exercise therapy (ET) compared to sham tDCS/+ET in patient with cervicogenic headache (CGH),DesignThis was a pilot sham-controlled, participant and assessor blinded, randomized controlled trial.MethodsThirty-two participants with CGH were randomized to active tDCS/+ET or sham tDCS/+ET. Participants completed 6-weeks of daily ET concurrently combined with 3 sessions per week of tDCS. Assessments included: craniocervical flexion test (mmHg), cervical isometric strength (N), cervical flexor and extensor endurance (seconds), and range of motion (degrees) pre-treatment, post-treatment, 6-weeks and 12-weeks post treatment. Linear mixed effect models evaluated group-time interactions at each follow-up while accounting for exercise program adherence and sex.ResultsThere were significant group-time interactions for activation scores on the craniocervical flexion test from pre-treatment to post-treatment (β = 1.571; 95%CI[0.155, 2.988]; p = 0.030), 6-weeks (β = 1.571; 95%CI[0.155, 2.988]; p = 0.030), and 12-weeks (β = 1.954; 95%CI[0.465, 3.443]; p = 0.011) favoring the active tDCS/+ET group.ConclusionsActive tDCS/+ET demonstrated significant benefits in deep cervical flexor motor control compared to sham tDCS/+ET that remained improved up to 12 weeks post-treatment. This suggests tDCS/+ET may improve of functional outcomes for patients with CGH.
目的 本研究的目的是评估与假经颅直流电刺激联合运动疗法（假tDCS/+ET）相比，经颅直流电刺激联合运动疗法（tDCS/+ET）对颈源性头痛（CGH）患者颈部运动控制、力量和耐力的功能结局。 设计 这是一项试点性假对照、参与者和评估者双盲、随机对照试验。 方法 32名CGH患者被随机分为tDCS/+ET组或假tDCS/+ET组。参与者每天进行6周的运动疗法，同时每周进行3次经颅直流电刺激。评估包括：颅颈屈曲试验（mmHg）、颈部等长力量（N）、颈部屈肌和伸肌耐力（秒）以及治疗前、治疗后、治疗后6周和12周的活动范围（度）。线性混合效应模型在考虑运动计划依从性和性别的同时，评估每次随访时的组间时间交互作用。 结果 从治疗前到治疗后（β=1.571；95%可信区间[0.155, 2.988]；p=0.030）、6周时（β=1.571；95%可信区间[0.155, 2.988]；p=0.030）和12周时（β=1.954；95%可信区间[0.465, 3.443]；p=0.011），颅颈屈曲试验激活评分存在显著的组间时间交互作用，有利于tDCS/+ET组。 结论 与假tDCS/+ET相比，tDCS/+ET在改善颈部深层屈肌运动控制方面显示出显著益处，且在治疗后12周仍保持改善。这表明tDCS/+ET可能改善CGH患者的功能结局。
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