Ögün Muhammed Nur, Çetinkaya Ayhan, Beyazçiçek Ersin
Bolu Abant Izzet Baysal Universitesi; Nöroloji Anabilim Dalı, Bolu, Türkiye.
Bolu Abant Izzet Baysal Universitesi; Fizyoloji Anabilim Dalı, Bolu, Türkiye.
Arq Neuropsiquiatr. 2019 Jul 15;77(6):412-417. doi: 10.1590/0004-282X20190064.
Vortioxetine is a multimodal antidepressant agent that modulates 5-HT receptors and inhibits the serotonin transporter. It is indicated especially in cases of major depressive disorder related to cognitive dysfunction. There are many studies investigating the effects of antidepressants on the seizure threshold and short-term epileptic activity. However, the effect of vortioxetine on epileptic seizures is not exactly known. Our aim was to investigate the effects of vortioxetine on penicillin-induced epileptiform activity. Twenty-seven Wistar rats were divided into three groups: sham-control group, positive control group (diazepam), and vortioxetine group. After a penicillin-induced epilepsy model was formed in each of the three groups of animals, 0.1 ml of saline was administered to the control group, 0.1 ml (10 mg/kg) vortioxetine was administered in the vortioxetine group, and 0.1 mL (5 mg/kg) of diazepam was administered in the positive control group, intraperitoneally. The epileptic activity records were obtained for 120 minutes after the onset of seizure. There was no significant difference in spike wave activity between the vortioxetine and diazepam groups, whereas this was significantly reduced in the vortioxetine group compared with the controls. The administration of vortioxetine at a dose of 10 mg/kg immediately after the seizure induction significantly decreased the spike frequencies of epileptiform activity compared with the control group. No significant difference was found between the vortioxetine and positive controls. This study showed that vortioxetine reduces the number of acutely-induced epileptic discharges. Vortioxetine may be an important alternative for epileptic patients with major depressive disorder-related cognitive dysfunction.
伏硫西汀是一种多模式抗抑郁药，可调节5-羟色胺（5-HT）受体并抑制5-羟色胺转运体。它尤其适用于与认知功能障碍相关的重度抑郁症病例。有许多研究探讨了抗抑郁药对癫痫发作阈值和短期癫痫活动的影响。然而，伏硫西汀对癫痫发作的影响尚不完全清楚。我们的目的是研究伏硫西汀对青霉素诱导的癫痫样活动的影响。将27只Wistar大鼠分为三组：假手术对照组、阳性对照组（地西泮）和伏硫西汀组。在三组动物中均建立青霉素诱导的癫痫模型后，对照组腹腔注射0.1 ml生理盐水，伏硫西汀组腹腔注射0.1 ml（10 mg/kg）伏硫西汀，阳性对照组腹腔注射0.1 ml（5 mg/kg）地西泮。癫痫发作开始后120分钟记录癫痫活动。伏硫西汀组和地西泮组的棘波活动无显著差异，而伏硫西汀组与对照组相比显著降低。癫痫诱导后立即给予10 mg/kg剂量的伏硫西汀，与对照组相比，癫痫样活动的棘波频率显著降低。伏硫西汀组与阳性对照组之间未发现显著差异。本研究表明，伏硫西汀可减少急性诱导的癫痫放电次数。对于患有与重度抑郁症相关认知功能障碍的癫痫患者，伏硫西汀可能是一种重要的替代药物。
