Ribeiro Marcelo, Trevizol Alisson Paulino, Frajzinger Rosana, Ribeiro Ariadne, Speierl Hannelore, Pires Luciana, Andraus Maristela, Tsanaclis Lolita, Alonso Ana Leonor Sala, Cordeiro Quirino, Laranjeira Ronaldo
Centro de Referência de Álcool, Tabaco e Outras Drogas (CRATOD), Secretaria de Saúde do Estado de São Paulo, São Paulo, SP, Brazil.
Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.
Trends Psychiatry Psychother. 2019 Jul 15;41(2):186-190. doi: 10.1590/2237-6089-2017-0143.
Brazil is the world's biggest consumer of crack cocaine, and dependence is a major public health issue. This is the first study to investigate the prevalence of potentially harmful adulterants present in hair samples from Brazilian patients with crack cocaine dependence.
We evaluated adulterants in hair samples extracted by convenience from 100 patients admitted at the 48 hour-observation unit of Centro de Referência de Álcool, Tabaco e Outras Drogas (CRATOD), Brazil's largest center for addiction treatment. A cross-sectional analysis was performed with the data obtained.
Adulterants were found in 97% of the analyzed hair samples. The most prevalent adulterant was lidocaine (92%), followed by phenacetin (69%) and levamisole (31%).
Adulterants were widely prevalent in hair samples from crack users treated at CRATOD: at least one adulterant was present in virtually all the hair samples collected. This points to a need to monitor adverse effects in the clinical setting in order to provide this high-risk group of patients with prompt and effective care related to the acute and chronic complications associated with these adulterants.
巴西是世界上最大的强效可卡因消费国，药物依赖是一个重大的公共卫生问题。这是第一项调查巴西强效可卡因依赖患者头发样本中潜在有害掺杂物流行情况的研究。
我们对从巴西最大的成瘾治疗中心——酒精、烟草及其他药物参考中心（CRATOD）的48小时观察病房中方便抽取的100名患者的头发样本中的掺杂物进行了评估。对所获数据进行了横断面分析。
在97%的分析头发样本中发现了掺杂物。最常见的掺杂物是利多卡因（92%），其次是非那西丁（69%）和左旋咪唑（31%）。
在CRATOD接受治疗的强效可卡因使用者的头发样本中，掺杂物广泛存在：几乎所有采集的头发样本中都至少有一种掺杂物。这表明有必要在临床环境中监测不良反应，以便为这一高危患者群体提供与这些掺杂物相关的急慢性并发症有关的及时有效的护理。
