Itakura T, Kamei I, Nakai K, Naka Y, Nakakita K, Imai H, Komai N
Department of Neurological Surgery, Wakayama Medical College, Japan.
J Neurosurg. 1988 Jun;68(6):955-9. doi: 10.3171/jns.1988.68.6.0955.
The superior cervical ganglion (SCG) of rats was transplanted into their own parietal cortex. Four weeks after implantation, catecholamine histofluorescence revealed many transplanted catecholamine cells in the cortex. However, no fibers extended from the transplanted tissue to the cerebral cortex. In a second group of rats which had been pretreated with 6-hydroxydopamine (a specific neurotoxin to the catecholamine neuron), some showed extension of catecholamine fibers to the cerebral cortex. To simulate an animal model of Parkinson's disease, MPTP (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine) was administered to five monkeys. Two weeks after MPTP administration, dopamine terminals in the caudate nucleus disappeared. After autotransplantation of the SCG into the caudate nucleus of these monkeys, many of the transplanted SCG cells extended axons beyond the graft into the caudate nucleus. These results show that transplanted SCG cells survived well in the brain. Under special circumstances, such as a shortage of catecholamine in the brain, implanted SCG cells extended their axons into the brain. It is suggested that autotransplantation of SCG grafts may be a new therapy for Parkinson's disease.
将大鼠的颈上神经节（SCG）移植到其自身的顶叶皮质中。植入四周后，儿茶酚胺组织荧光显示皮质中有许多移植的儿茶酚胺细胞。然而，没有纤维从移植组织延伸至大脑皮质。在第二组用6-羟基多巴胺（一种对儿茶酚胺神经元的特异性神经毒素）预处理过的大鼠中，一些大鼠显示儿茶酚胺纤维延伸至大脑皮质。为模拟帕金森病动物模型，给五只猴子注射了MPTP（1-甲基-4-苯基-1,2,5,6-四氢吡啶）。注射MPTP两周后，尾状核中的多巴胺终末消失。将SCG自体移植到这些猴子的尾状核后，许多移植的SCG细胞将轴突延伸至移植物之外并进入尾状核。这些结果表明，移植的SCG细胞在脑中存活良好。在特殊情况下，如脑内儿茶酚胺缺乏时，植入的SCG细胞会将其轴突延伸至脑内。提示SCG移植物自体移植可能是治疗帕金森病的一种新方法。
