Nakai M, Itakura T, Kamei I, Nakai K, Naka Y, Imai H, Komai N
Department of Neurological Surgery, Wakayama Medical College, Japan.
J Neurosurg. 1990 Jan;72(1):91-5. doi: 10.3171/jns.1990.72.1.0091.
The effect of autologous transplantation of the superior cervical ganglion (SCG) into the brain of parkinsonian monkeys was studied through quantitative measurement of animal behavior. The motor activity of the monkey was measured with a telemetry system during the experiment. After experimental parkinsonism was induced by repeated intravenous injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), three monkeys were treated with autologous transplantation of the SCG into both caudate nuclei. One monkey served as a control without SCG transplantation after MPTP treatment. Three SCG-transplanted monkeys showed biphasic (acute and chronic) behavioral amelioration of parkinsonism after transplantation. In the acute stage, the animals showed transient hyperkinesia with aggressive behavior and loss of circadian rhythm. In the chronic stage following acute hyperkinesia, the animals regained normal behavior and circadian rhythm without aggressiveness. In contrast with the transplanted monkeys, the control monkey failed to show recovery of the bradykinesia and muscle rigidity.
通过对动物行为的定量测量，研究了将颈上神经节（SCG）自体移植到帕金森病猴脑内的效果。实验期间，用遥测系统测量猴子的运动活动。通过反复静脉注射1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导实验性帕金森病后，对三只猴子进行双侧尾状核的SCG自体移植。一只猴子在MPTP处理后作为未进行SCG移植的对照。三只接受SCG移植的猴子在移植后帕金森病症状出现双相（急性和慢性）改善。在急性期，动物表现出短暂的运动亢进、攻击行为和昼夜节律丧失。在急性运动亢进后的慢性期，动物恢复了正常行为和昼夜节律，且无攻击行为。与移植的猴子相比，对照猴的运动迟缓及肌肉僵硬未出现恢复。
