猪心异种移植传播猪圆环病毒 3 型（PCV3）。
Transmission of Porcine Circovirus 3 (PCV3) by Xenotransplantation of Pig Hearts into Baboons.
机构信息
Robert Koch Institute, HIV and other retroviruses, 13353 Berlin, Germany.
Department of Anaesthesiology, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
出版信息
Viruses. 2019 Jul 16;11(7):650. doi: 10.3390/v11070650.
Porcine circovirus 3 (PCV3) is a newly described member of the virus family Circoviridae. PCV3 is highly distributed among pigs and wild boars worldwide. A sudden introduction of PCV3 was recently observed in a herd of triple genetically modified pigs generated for xenotransplantation. These animals were used as donor pigs for orthotopic heart transplantation into baboons. In four cases, PCV3-positive hearts were transplanted, and transmission of PCV3 to the recipient was observed. PCV3 was found in all organs of the recipient baboons and a higher virus load was found in animals with a longer survival time of the transplant, indicating replication of the virus. This is the first report showing trans-species transmission of PCV3 to baboons by transplantation of a heart from a PCV3-positive donor pig. Sequence analysis showed that PCV3a and PCV3b were present in the infected pigs and were transmitted. Experiments to infect human 293 cells with PCV3 failed.
猪圆环病毒 3 型（PCV3）是圆环病毒科病毒家族的一个新成员。PCV3 在全世界的猪和野猪中广泛分布。最近在一群用于异种移植的三重基因修饰猪中观察到了 PCV3 的突然引入。这些动物被用作将心脏原位移植到狒狒体内的供体猪。在 4 例中，移植了 PCV3 阳性心脏，并观察到 PCV3 向受体的传播。在接受者的所有器官中都发现了 PCV3，并且在移植存活时间较长的动物中发现了更高的病毒载量，表明病毒复制。这是首例通过移植来自 PCV3 阳性供体猪的心脏将 PCV3 跨物种传播给狒狒的报告。序列分析表明，感染猪中存在 PCV3a 和 PCV3b，并进行了传播。用 PCV3 感染人 293 细胞的实验失败。
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