Badawy Ahmed, Hassanean Hashim, Ibrahim Amany K, Habib Eman S, El-Magd Mohammed A, Ahmed Safwat A
Department of Pharmacognosy, Faculty of Pharmacy, Sinai University, El-Arish, Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Nat Prod Res. 2021 Jun;35(11):1799-1807. doi: 10.1080/14786419.2019.1643859. Epub 2019 Jul 17.
Herein, we investigated effect of Thymelaea hirsuta isolates on hepatocellular carcinoma. Methanolic extract of led to isolation of two new compounds [6` hydroxyDaphnoretin (9) and Mithnin (15)], seven compounds reported for the first time from genus Thymelaea [Dotriacontanol (1), and 3-ketopentatriacontanoic (2), Docosylcoumarate (5), Docosylcaffeate (6), Daphnodorin B (11), 3`` -epi-dihydrodaphnodorin B (12) and Wikstaiwanone B (14)], and six known compounds. Eight compounds (5, 6, 9, 10, 11, 12, 14, and 15) showed significant anti-proliferative activity on HepG2 cells. These compounds caused significant reduction (p < 0.05) in serum levels of AST, ALT, ALP, total bilirubin, GGT, and AFP, a significant increase in and expression, and a significant decrease in gene in liver as compared to the HCC group. These results indicate that isolates inhibited HCC progression, possibly through induction of apoptosis and therefore they could be used as a beneficial source for treating HCC.
在此，我们研究了多毛瑞香分离物对肝细胞癌的影响。其甲醇提取物导致分离出两种新化合物[6`-羟基瑞香素（9）和米斯宁（15）]、七种首次从瑞香属报道的化合物[三十二烷醇（1）、3-氧代三十五烷酸（2）、二十二烷基香豆酸酯（5）、二十二烷基咖啡酸酯（6）、瑞香多灵B（11）、3``-表二氢瑞香多灵B（12）和维克台湾酮B（14）]以及六种已知化合物。八种化合物（5、6、9、10、11、12、14和15）对HepG2细胞显示出显著的抗增殖活性。与肝癌组相比，这些化合物使血清中AST、ALT、ALP、总胆红素、GGT和AFP水平显著降低（p < 0.05），使肝脏中 和 表达显著增加， 基因显著减少。这些结果表明，多毛瑞香分离物可能通过诱导细胞凋亡抑制肝癌进展，因此它们可作为治疗肝癌的有益来源。 （注：原文中部分表述不完整，如“a significant increase in and expression”以及“a significant decrease in gene”中缺失具体内容，但按要求进行了完整翻译）
