Correlation between gene polymorphisms and lone atrial fibrillation risk.

Atrial electrical remodelling (AER) was significantly associated with atrial fibrillation (AF) development. Polymorphisms in hyperpolarization activated cyclic nucleotide gated potassium channel 4 () gene might be correlated with AER. In the present study, we explored the association of polymorphisms (rs498005 and rs7164883) with lone AF risk in a Chinese Han population. In this case-control study, the Sanger sequencing method was utilized to genotype the polymorphisms. Relative risk of AF was assessed by the test, and presented by odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Logistic regression analysis was performed for multivariate analysis. The effects of polymorphisms on AF clinical features were analyzed by the Mann-Whitney test and adjusted by the Bonferroni method. C allele of rs498005 was significantly correlated with increased risk of AF (OR = 1.412, 95%CI = 1.012-1.970), and the association still exited after adjustment by age, gender, the status of smoking and drinking, histories of diabetes, hyperlipidaemia and myocardial infarction (adjusted OR = 1.473, 95%CI = 1.043-2.081). G allele of rs7164883 SNP was marginally associated with enhanced AF risk after adjustment by the above clinical parameters (adjusted OR = 1.742, 95%CI = 1.019-2.980). Atrial late potential (ALP), including TP (P wave duration after filtering) and LP (the amplitude of superimposed potential in the final 20 ms of P wave) were significantly associated with rs498005 genotype ( < .001). rs498005 and rs7164883 polymorphisms are significantly associated with AF risk.