Department of Obstetrics and Gynaecology, Women's College Hospital , Toronto , ON , Canada.
Department of Obstetrics and Gynaecology, Sinai Health System , Toronto , ON , Canada.
Climacteric. 2019 Dec;22(6):603-609. doi: 10.1080/13697137.2019.1635580. Epub 2019 Jul 18.
Hematopoietic cell transplantation (HCT) is associated with well-described gynecologic sequelae, including vulvovaginal graft-versus-host disease (GVHD). Vulvovaginal GVHD is a common complication of allogeneic HCT, but has been under-reported in the literature. Guidelines have been published only recently to recommend common terminology, treatment, and surveillance. This review summarizes the presentation, management, and surveillance aspects of vulvovaginal GVHD. We recommend a standardized referral between women undergoing HCT and an experienced gynecologist capable of managing this disease and treating sexual side effects.
造血细胞移植（HCT）与明确的妇科后遗症相关，包括外阴阴道移植物抗宿主病（GVHD）。外阴阴道 GVHD 是同种异体 HCT 的常见并发症，但在文献中报道较少。最近才发布了指南，以推荐常见的术语、治疗和监测。这篇综述总结了外阴阴道 GVHD 的表现、治疗和监测方面。我们建议在接受 HCT 的女性与能够管理这种疾病和治疗性副作用的有经验的妇科医生之间进行标准化转诊。
