McGill University, Montreal, Quebec, Canada.
J Aging Health. 2020 Aug-Sep;32(7-8):892-903. doi: 10.1177/0898264319862419. Epub 2019 Jul 17.
Literature suggests C-reactive protein (CRP)-as a marker of low-grade systemic inflammation-may mediate the linkage between chronic stressors and cardiometabolic conditions. Previous population-based reports are based on weak methodologies and may have yielded incorrect inferences. The current study examined linkages of within-person CRP variation with corresponding variation in stressor burdens. Data were from the 2006, 2010, and 2014 waves of the U.S. Health and Retirement Study. Analysis was through unit fixed effects and first-difference estimators. Both gender-combined and gender-specific models were run. In none of the analyses was CRP positively associated with chronic stressors. This was true among both genders, and in models of linear as well as nonlinear change. Results held in a series of separate robustness checks. CRP may not mediate the social etiology of degenerative diseases. Population representative evidence of inflammation's role in these processes remains absent.
文献表明，C 反应蛋白（CRP）作为低度全身炎症的标志物，可能在慢性应激源与心血管代谢状况之间起中介作用。先前基于人群的报告所采用的方法较弱，可能得出了错误的推论。本研究检验了个体内 CRP 变化与应激源负担相应变化之间的联系。数据来自 2006 年、2010 年和 2014 年美国健康与退休研究的调查。分析采用单位固定效应和一阶差分估计量。同时进行了男女混合模型和性别特异性模型的分析。在任何分析中，CRP 均与慢性应激源无正向关联。这在两性中、在线性和非线性变化模型中均成立。一系列单独的稳健性检验结果也支持这一结论。CRP 可能不是退行性疾病的社会病因学的中介。关于炎症在这些过程中作用的人群代表性证据仍然缺乏。
