Chronic Ongoing Stressors and C-Reactive Protein: A Within-Person Study.

Literature suggests C-reactive protein (CRP)-as a marker of low-grade systemic inflammation-may mediate the linkage between chronic stressors and cardiometabolic conditions. Previous population-based reports are based on weak methodologies and may have yielded incorrect inferences. The current study examined linkages of within-person CRP variation with corresponding variation in stressor burdens. Data were from the 2006, 2010, and 2014 waves of the U.S. Health and Retirement Study. Analysis was through unit fixed effects and first-difference estimators. Both gender-combined and gender-specific models were run. In none of the analyses was CRP positively associated with chronic stressors. This was true among both genders, and in models of linear as well as nonlinear change. Results held in a series of separate robustness checks. CRP may not mediate the social etiology of degenerative diseases. Population representative evidence of inflammation's role in these processes remains absent.