Zhang Yi, Buzukela Abuduaini, Peng Peng
Department of Emergency, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China. Corresponding author: Peng Peng, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Jun;31(6):785-788. doi: 10.3760/cma.j.issn.2095-4352.2019.06.025.
Sepsis-induced myocardial dysfunction (SIMD) has a high morbidity and mortality, and seriously threatens human health. However, the pathogenesis of the SIMD is still unclear. The previous studies have showed that the SIMD can adversely affect cardiac function through a variety of direct or indirect mechanism, such as autonomic nervous system function damage, pro-inflammatory mediators and activated immune cells induced cardiomyopathy. There is no uniform diagnostic criteria and treatment options. A stable and reliable animal model plays important role in the study that determine the pathogenesis, pathophysiological processes and treatment of SIMD. At present, there are many animal models of cardiac dysfunction caused by sepsis, unfortunately there is no stable, reliable and specific animal model at present. Therefore, it is important to construct a stable and reliable model for studying SIMD. The unified standard of cardiac dysfunction is conducive to the integration and further research. This review focused on pathogenesis of SIMD, routine ways of animal model of SIMD, observation index and basic research to provide references for the researcher to choose the proper animal model.
脓毒症诱导的心肌功能障碍（SIMD）发病率和死亡率高，严重威胁人类健康。然而，SIMD的发病机制仍不清楚。先前的研究表明，SIMD可通过多种直接或间接机制对心脏功能产生不利影响，如自主神经系统功能损害、促炎介质和活化免疫细胞诱导的心肌病。目前尚无统一的诊断标准和治疗方案。稳定可靠的动物模型在确定SIMD的发病机制、病理生理过程和治疗的研究中起着重要作用。目前有许多脓毒症所致心脏功能障碍的动物模型，遗憾的是目前尚无稳定、可靠且特异的动物模型。因此，构建稳定可靠的模型对于研究SIMD很重要。心脏功能障碍的统一标准有利于整合和进一步研究。本文综述聚焦于SIMD的发病机制、SIMD动物模型的常规构建方法、观察指标及基础研究，为研究者选择合适的动物模型提供参考。
