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2017 年至 2020 年间，在一家单中心对 42 例脓毒症性心肌功能障碍患者的白细胞介素 8 血浆水平进行回顾性观察研究。

A Retrospective Observational Study of the Association Between Plasma Levels of Interleukin 8 in 42 Patients with Sepsis-Induced Myocardial Dysfunction at a Single Center Between 2017 and 2020.

机构信息

Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland).

Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland).

出版信息

Med Sci Monit. 2021 Dec 1;27:e933065. doi: 10.12659/MSM.933065.

DOI:10.12659/MSM.933065
PMID:34897267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8647454/
Abstract

BACKGROUND This retrospective, observational study from a single center aimed to evaluate the association between complement (C)3 and C4, lymphocytes markers CD4 and CD8, and the interleukins IL-1ß, IL-2R, IL-6, IL-10, and IL-8 in patients with sepsis-induced myocardial dysfunction (SIMD) and a reduced left ventricular ejection fraction (LVEF) of < 50%. MATERIAL AND METHODS Patients with sepsis from July 2017 to December 2020 were divided into a SIMD group (42 patients) and NO-SIMD group (214 patients). Diagnostic criteria of sepsis were based on SEPSIS 3.0 guidelines. SIMD was defined as LVEF.

摘要

背景

本回顾性观察性研究来自单一中心，旨在评估补体（C）3 和 C4、淋巴细胞标志物 CD4 和 CD8，以及白细胞介素 IL-1β、IL-2R、IL-6、IL-10 和 IL-8 在合并脓毒症性心肌功能障碍（SIMD）和左心室射血分数（LVEF）<50%降低的患者中的相关性。

材料和方法

2017 年 7 月至 2020 年 12 月，将脓毒症患者分为 SIMD 组（42 例）和非 SIMD 组（214 例）。脓毒症的诊断标准基于 SEPSIS 3.0 指南。SIMD 定义为 LVEF。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1e2/8647454/cc885a442c6e/medscimonit-27-e933065-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1e2/8647454/6b5a8137bc2f/medscimonit-27-e933065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1e2/8647454/cc885a442c6e/medscimonit-27-e933065-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1e2/8647454/6b5a8137bc2f/medscimonit-27-e933065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1e2/8647454/cc885a442c6e/medscimonit-27-e933065-g002.jpg

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