Hao Yujie, Liu Runmin, Wang Hao, Rui Tao, Guo Junfang
Division of Cardiology, Department of Medicine, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
Int J Gen Med. 2024 Aug 5;17:3387-3393. doi: 10.2147/IJGM.S472846. eCollection 2024.
Sepsis is a syndrome of organ dysfunction caused by a dysregulated immune response to infection, with high morbidity and mortality. At present, there have been many advances in the study of its pathogenesis, especially the cardiac dysfunction caused by sepsis, namely sepsis-induced myocardial dysfunction, SIMD, which has received widespread attention. The mechanisms of SIMD mainly include excessive release of inflammatory mediators, impaired mitochondrial function, autophagy, apoptosis and myocardial dysfunction. This article reviews the pathogenesis of SIMD and elaborates on the progress in its treatment, aiming to improve the prognosis of patients with SIMD and sepsis.
脓毒症是一种因对感染的免疫反应失调而导致器官功能障碍的综合征，发病率和死亡率都很高。目前，其发病机制的研究已有诸多进展，尤其是脓毒症所致的心脏功能障碍，即脓毒症诱导的心肌功能障碍（SIMD），已受到广泛关注。SIMD的机制主要包括炎症介质的过度释放、线粒体功能受损、自噬、凋亡以及心肌功能障碍。本文综述了SIMD的发病机制，并阐述了其治疗进展，旨在改善SIMD和脓毒症患者的预后。
