适应逆境：肠球菌中应激耐受与发病机制的交织。
Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci.
机构信息
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Microbiol Mol Biol Rev. 2019 Jul 17;83(3). doi: 10.1128/MMBR.00008-19. Print 2019 Aug 21.
Abstract
is a diverse and rugged genus colonizing the gastrointestinal tract of humans and numerous hosts across the animal kingdom. Enterococci are also a leading cause of multidrug-resistant hospital-acquired infections. In each of these settings, enterococci must contend with changing biophysical landscapes and innate immune responses in order to successfully colonize and transit between hosts. Therefore, it appears that the intrinsic durability that evolved to make enterococci optimally competitive in the host gastrointestinal tract also ideally positioned them to persist in hospitals, despite disinfection protocols, and acquire new antibiotic resistances from other microbes. Here, we discuss the molecular mechanisms and regulation employed by enterococci to tolerate diverse stressors and highlight the role of stress tolerance in the biology of this medically relevant genus.
摘要
是一个多样化且坚韧的属，定植于人类和动物王国中众多宿主的胃肠道中。肠球菌也是导致多药耐药性医院获得性感染的主要原因。在这些环境中的每一种情况下，肠球菌都必须应对不断变化的生物物理景观和先天免疫反应，以便在宿主之间成功定植和转移。因此，肠球菌在宿主胃肠道中进化出的固有耐久性似乎使它们能够在医院中持续存在，尽管有消毒方案，但也使它们能够从其他微生物中获得新的抗生素耐药性。在这里，我们讨论了肠球菌用来耐受各种应激源的分子机制和调控，并强调了应激耐受性在这个具有医学相关性的属的生物学中的作用。
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