影响范围：含有病毒癌基因的上皮细胞的基质调节。
mSphere of Influence: Stromal Regulation of Epithelium Containing Viral Oncogenes.
机构信息
Department of Microbiology and Immunology, LSU Health Sciences Center-Shreveport, Shreveport, Louisiana, USA
出版信息
mSphere. 2019 Jul 17;4(4):e00467-19. doi: 10.1128/mSphere.00467-19.
Abstract
Jason Bodily works in the field of tumor virology. In this mSphere of Influence article, he reflects on how "Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion" by Adam Pickard et al. (EMBO J 31:3092-3103, 2012, https://doi.org/10.1038/emboj.2012.153) has impacted his work by making him think about the role of stromal cells in human papillomavirus infections.
摘要
杰森·博迪利（Jason Bodily）从事肿瘤病毒学领域的工作。在这篇 mSphere 影响力文章中，他反思了亚当·皮卡德（Adam Pickard）等人的研究成果“基质成纤维细胞中 Rb 的失活促进上皮细胞浸润”（EMBO J 31:3092-3103, 2012, https://doi.org/10.1038/emboj.2012.153）如何通过促使他思考基质细胞在人类乳头瘤病毒感染中的作用，对他的工作产生了影响。
相似文献
1
mSphere of Influence: Stromal Regulation of Epithelium Containing Viral Oncogenes.影响范围：含有病毒癌基因的上皮细胞的基质调节。
mSphere. 2019 Jul 17;4(4):e00467-19. doi: 10.1128/mSphere.00467-19.
2
mSphere of Influence: MmuPV1-a dual tropic papillomavirus, red herring, or novel insight into HPV pathogenesis.影响范围：MmuPV1——一种双嗜性乳头瘤病毒，是转移注意力的事物还是 HPV 发病机制的新见解。
mSphere. 2024 Jul 30;9(7):e0017724. doi: 10.1128/msphere.00177-24. Epub 2024 Jun 26.
3
mSphere of Influence: Retreading old ground-the beauty in multi-omic data sets.影响范围：重走老路——多组学数据集的魅力。
mSphere. 2024 Jun 25;9(6):e0013124. doi: 10.1128/msphere.00131-24. Epub 2024 May 15.
4
mSphere of Influence: the Value of Simplicity in Experiments and Solidarity among Lab Members.影响范围：实验的简洁性和实验室成员的团结的价值。
mSphere. 2019 Jun 19;4(3):e00172-19. doi: 10.1128/mSphere.00172-19.
5
Human papillomaviruses and cell signaling.人乳头瘤病毒与细胞信号传导。
Sci STKE. 2005 Jun 14;2005(288):pe29. doi: 10.1126/stke.2882005pe29.
6
[P53 protein and human papillomavirus oncogenes in carcinogenesis of the uterine cervix].[P53蛋白与人乳头瘤病毒癌基因在子宫颈癌发生中的作用]
Rev Invest Clin. 1996 Jan-Feb;48(1):59-68.
7
mSphere of Influence: Turning to Soil for Medicines.影响范围：从土壤中寻找药物。
mSphere. 2021 Jan 6;6(1):e01258-20. doi: 10.1128/mSphere.01258-20.
8
mSphere of Influence: Interferon Ultra Is a Means To Fight Viral Disease.影响范围：干扰素是对抗病毒疾病的一种手段。
mSphere. 2020 Mar 25;5(2):e00134-20. doi: 10.1128/mSphere.00134-20.
9
Epithelial-stromal interactions modulating penetration of matrigel membranes by HPV 16-immortalized keratinocytes.上皮-基质相互作用调节人乳头瘤病毒16型永生化角质形成细胞对基质胶膜的穿透
J Invest Dermatol. 1997 Nov;109(5):619-25. doi: 10.1111/1523-1747.ep12337594.
10
In vitro experimental systems for HPV: epithelial raft cultures for investigations of viral reproduction and pathogenesis and for genetic analyses of viral proteins and regulatory sequences.用于人乳头瘤病毒（HPV）的体外实验系统：上皮筏培养物，用于研究病毒复制和发病机制以及病毒蛋白和调控序列的基因分析。
Clin Dermatol. 1997 Mar-Apr;15(2):217-27. doi: 10.1016/s0738-081x(97)00069-2.
本文引用的文献
1
Immunological hallmarks of stromal cells in the tumour microenvironment.肿瘤微环境中基质细胞的免疫特征。
Nat Rev Immunol. 2015 Nov;15(11):669-82. doi: 10.1038/nri3902. Epub 2015 Oct 16.
2
The RB tumor suppressor at the intersection of proliferation and immunity: relevance to disease immune evasion and immunotherapy.处于增殖与免疫交叉点的RB肿瘤抑制因子：与疾病免疫逃逸及免疫治疗的相关性
Cell Cycle. 2015;14(24):3812-9. doi: 10.1080/15384101.2015.1010922.
3
Non-cell-autonomous tumor suppression by p53.p53 非细胞自主的肿瘤抑制作用。
Cell. 2013 Apr 11;153(2):449-60. doi: 10.1016/j.cell.2013.03.020. Epub 2013 Apr 4.
4
Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion.Rb 在基质成纤维细胞中的失活促进上皮细胞侵袭。
EMBO J. 2012 May 29;31(14):3092-103. doi: 10.1038/emboj.2012.153.
5
Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells.Rb/E2F1 调控上皮细胞中的先天免疫受体 Toll 样受体 3。
Mol Cell Biol. 2012 Apr;32(8):1581-90. doi: 10.1128/MCB.06454-11. Epub 2012 Feb 6.
6
Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.视网膜母细胞瘤肿瘤抑制因子的缺失：对与细胞周期控制和免疫功能相关的转录程序的不同作用。
Oncogene. 2007 Sep 20;26(43):6307-18. doi: 10.1038/sj.onc.1210450. Epub 2007 Apr 23.
7
Tumor-stroma interactions.肿瘤-基质相互作用
Curr Opin Genet Dev. 2005 Feb;15(1):97-101. doi: 10.1016/j.gde.2004.12.003.
8
Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.干扰素-α/β信号与p53反应在肿瘤抑制和抗病毒防御中的整合。
Nature. 2003 Jul 31;424(6948):516-23. doi: 10.1038/nature01850.
Zotero 插件