影响范围：重走老路——多组学数据集的魅力。
mSphere of Influence: Retreading old ground-the beauty in multi-omic data sets.
机构信息
School of Life Sciences, University of Sussex, Brighton, United Kingdom.
出版信息
mSphere. 2024 Jun 25;9(6):e0013124. doi: 10.1128/msphere.00131-24. Epub 2024 May 15.
Ethan L. Morgan works on human papillomaviruses (HPVs), with a specific interest in identifying how HPV induces tumor formation. In this mSphere of Influence article, he reflects on how three papers influenced him. "Comprehensive genomic characterization of head and neck squamous cell carcinomas" (The Cancer Genome Atlas Network, Nature 517:576-582, 2015, https://doi.org/10.1038/nature14129) and "Integrated genomic and molecular characterization of cervical cancer" (The Cancer Genome Atlas Network, Nature 543: 378-384, 2017, https://doi.org/10.1038/nature21386) showed him the power behind comprehensive multi-omic analyses to understand disease biology, while "Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response" (J. Sitz et al., Proc Natl Acad Sci U S A 116:19552-19562, 2019, https://doi.org/10.1073/pnas.1906102116) reinforced how this can be used to undercover potential new drug targets in HPV-associated disease.
伊桑·L·摩根（Ethan L. Morgan）从事人类乳头瘤病毒（HPV）的研究，特别关注 HPV 如何诱导肿瘤形成。在这篇 mSphere 影响力文章中，他反思了三篇论文如何影响了他。“头颈部鳞状细胞癌的综合基因组特征”（The Cancer Genome Atlas Network，Nature 517：576-582，2015，https://doi.org/10.1038/nature14129）和“宫颈癌的综合基因组和分子特征”（The Cancer Genome Atlas Network，Nature 543：378-384，2017，https://doi.org/10.1038/nature21386）向他展示了全面的多组学分析在理解疾病生物学方面的强大力量，而“人类乳头瘤病毒 E7 癌蛋白靶向 RNF168 劫持宿主 DNA 损伤反应”（J. Sitz 等人，Proc Natl Acad Sci U S A 116：19552-19562，2019，https://doi.org/10.1073/pnas.1906102116）则强化了如何利用这一方法来发现 HPV 相关疾病中的潜在新药物靶点。
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