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本文引用的文献

1
Surgical fixation methods for tibial plateau fractures.胫骨平台骨折的手术固定方法。
Cochrane Database Syst Rev. 2015 Sep 15;2015(9):CD009679. doi: 10.1002/14651858.CD009679.pub2.
2
Augmentation of tibial plateau fractures with an injectable bone substitute: CERAMENT™. Three year follow-up from a prospective study.使用可注射骨替代物CERAMENT™增强胫骨平台骨折:一项前瞻性研究的三年随访
BMC Musculoskelet Disord. 2015 May 13;16:115. doi: 10.1186/s12891-015-0574-6.
3
CERAMENT treatment of fracture defects (CERTiFy): protocol for a prospective, multicenter, randomized study investigating the use of CERAMENT™ BONE VOID FILLER in tibial plateau fractures.CERAMENT 治疗骨折缺损(CERTiFY):一项前瞻性、多中心、随机研究的方案,旨在研究 CERAMENT™ 骨空洞填充剂在胫骨平台骨折中的应用。
Trials. 2014 Mar 8;15:75. doi: 10.1186/1745-6215-15-75.
4
Bone healing using a bi-phasic ceramic bone substitute demonstrated in human vertebroplasty and with histology in a rabbit cancellous bone defect model.在人体椎体成形术中使用双相陶瓷骨替代物进行骨愈合,并在兔松质骨缺损模型中进行组织学研究。
Interv Neuroradiol. 2012 Mar;18(1):105-13. doi: 10.1177/159101991201800114. Epub 2012 Mar 16.
5
Tibial plateau fracture repairs augmented with calcium phosphate cement have higher in situ fatigue strength than those with autograft.用磷酸钙骨水泥增强的胫骨平台骨折修复比自体移植物的原位疲劳强度更高。
J Orthop Trauma. 2011 Feb;25(2):90-5. doi: 10.1097/BOT.0b013e3181e3e28f.
6
Bioceramic vertebral augmentation with a calcium sulphate/hydroxyapatite composite (Cerament SpineSupport): in vertebral compression fractures due to osteoporosis.生物陶瓷骨水泥增强硫酸钙/羟基磷灰石复合材料(Cerament SpineSupport)在骨质疏松性椎体压缩骨折中的应用。
Eur Spine J. 2010 Jun;19(6):887-92. doi: 10.1007/s00586-010-1279-z. Epub 2010 Feb 4.
7
Osteotomy of distal radius fracture malunion using a fast remodeling bone substitute consisting of calcium sulphate and calcium phosphate.使用由硫酸钙和磷酸钙组成的快速重塑骨替代物对桡骨远端骨折畸形愈合进行截骨术。
J Biomed Mater Res B Appl Biomater. 2010 Jan;92(1):281-6. doi: 10.1002/jbm.b.31524.
8
Comparison of autogenous bone graft and endothermic calcium phosphate cement for defect augmentation in tibial plateau fractures. A multicenter, prospective, randomized study.自体骨移植与吸热型磷酸钙骨水泥用于胫骨平台骨折缺损增大的比较:一项多中心、前瞻性、随机研究。
J Bone Joint Surg Am. 2008 Oct;90(10):2057-61. doi: 10.2106/JBJS.G.01191.
9
The use of calcium phosphate bone cement in fracture treatment. A meta-analysis of randomized trials.磷酸钙骨水泥在骨折治疗中的应用。随机试验的荟萃分析。
J Bone Joint Surg Am. 2008 Jun;90(6):1186-96. doi: 10.2106/JBJS.G.00241.
10
Substitutes for autologous bone graft in orthopaedic trauma.骨科创伤中自体骨移植的替代物
J Bone Joint Surg Br. 2001 Jan;83(1):3-8. doi: 10.1302/0301-620x.83b1.11952.

双相骨水泥替代物在干骺端骨折治疗中的应用。

Use of a biphasic cement bone substitute in the management of metaphyseal fractures.

作者信息

Yeo Quan You, Kee Kwek Ernest Beng

机构信息

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

出版信息

J Clin Orthop Trauma. 2019 Jul-Aug;10(4):789-791. doi: 10.1016/j.jcot.2018.08.014. Epub 2018 Aug 10.

DOI:10.1016/j.jcot.2018.08.014
PMID:31316256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6611836/
Abstract

OBJECTIVES

In recent years, the increase in utilisation of bone substitutes in the reconstruction of bone defects has been fuelled by donor site complications associated with autologous bone harvesting. However the ability of bone substitute to stimulate bone union while maintaining fracture reduction has been a topic of debate. Cerament Bone Void Filler (CBVF) is a novel biphasic and injectable ceramic bone substitute that has high compressive strength and the ability to promote cancellous bone healing.

MATERIALS AND METHOD

This is a retrospective study to evaluate the surgical outcome of utilising CBVF in the treatment of depressed metaphyseal bone fractures over a two year period. The patients were followed up for at least six months after surgery and clinical parameters such as wound site complications were collated. Radiographic imaging was evaluated to determine loss of fracture reduction and rate of cement resorption.

RESULTS

Thirteen patients with depressed metaphyseal fractures were enrolled, which included: (i) one proximal humerus fracture; (ii) three tibial plateau fractures; and (iii) nine calcaneal fractures. None of the patients showed significant collapse in fracture reduction after six months of follow up. Cement resorption was noted in one patient as early as three weeks after surgery. There were no cases of cement leak or wound site complications.

CONCLUSION

Cerament Bone Void Filler (CBVF) is a promising bone graft substitute in the management of depressed metaphyseal bone fractures, with the ability to maintain fracture reduction despite cement resorption.

摘要

目的

近年来,与自体骨采集相关的供区并发症推动了骨替代物在骨缺损重建中应用的增加。然而,骨替代物在维持骨折复位的同时刺激骨愈合的能力一直是一个有争议的话题。Cerament骨缺损填充剂(CBVF)是一种新型的双相可注射陶瓷骨替代物,具有高抗压强度和促进松质骨愈合的能力。

材料与方法

这是一项回顾性研究,旨在评估在两年期间使用CBVF治疗干骺端凹陷性骨折的手术效果。术后对患者进行至少六个月的随访,并整理伤口部位并发症等临床参数。评估影像学检查结果以确定骨折复位丢失情况和骨水泥吸收速率。

结果

纳入13例干骺端凹陷性骨折患者,其中包括:(i)1例肱骨近端骨折;(ii)3例胫骨平台骨折;以及(iii)9例跟骨骨折。随访六个月后,所有患者均未出现明显的骨折复位塌陷。有1例患者在术后三周就出现了骨水泥吸收。未发生骨水泥渗漏或伤口部位并发症。

结论

Cerament骨缺损填充剂(CBVF)在治疗干骺端凹陷性骨折方面是一种有前景的骨移植替代物,尽管存在骨水泥吸收,但仍有维持骨折复位的能力。