微小RNA-876-5p通过靶向转录因子AP-2α抑制乳腺癌进展。
miR-876-5p suppresses breast cancer progression through targeting TFAP2A.
作者信息
Xu Jie, Zheng Jie, Wang Jian, Shao Jianping
机构信息
Department of Breast Surgery, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China.
出版信息
Exp Ther Med. 2019 Aug;18(2):1458-1464. doi: 10.3892/etm.2019.7689. Epub 2019 Jun 18.
Abstract
MicroRNAs (miRNAs) are widely expressed in human cells and closely associated with various types of cancer, including breast cancer. miR-876-5p has been indicated to participate in the tumorigenesis of certain types of cancer, such as hepatocellular carcinoma. Nevertheless, the roles of miR-876-5p in breast cancer remain unclear. In the present study, it was revealed that miR-876-5p expression levels were decreased in breast cancer cells compared with a normal cell line. miR-876-5p ectopic expression suppressed breast cancer cell proliferation and arrested progression of the cell cycle. In addition, miR-876-5p suppressed breast cancer cell migration and invasion. miR-876-5p was demonstrated to directly target transcription factor AP-2-α (TFAP2A) in breast cancer cells, and restoration of TFAP2A rescinded the suppressive role of miR-876-5p. In summary, the results from the present study provide evidence that miR-876-5p suppresses breast cancer progression by regulating cell proliferation, migration and invasion in a TFAP2A-dependent manner.
摘要
微小RNA（miRNA）在人类细胞中广泛表达，并与包括乳腺癌在内的各种类型癌症密切相关。已有研究表明，miR-876-5p参与某些类型癌症的肿瘤发生过程，如肝细胞癌。然而，miR-876-5p在乳腺癌中的作用仍不清楚。在本研究中，结果显示与正常细胞系相比，乳腺癌细胞中miR-876-5p的表达水平降低。miR-876-5p的异位表达抑制了乳腺癌细胞的增殖，并使细胞周期进程停滞。此外，miR-876-5p抑制了乳腺癌细胞的迁移和侵袭。研究证实，miR-876-5p在乳腺癌细胞中直接靶向转录因子AP-2-α（TFAP2A），而TFAP2A的恢复消除了miR-876-5p的抑制作用。总之，本研究结果提供了证据，表明miR-876-5p通过以TFAP2A依赖的方式调节细胞增殖、迁移和侵袭来抑制乳腺癌进展。
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