Al-Jawad Faruk H, Al-Attar Zaid, Abbood Muayyad S
Department of Pharmacology & Therapeutics, Al-Nahrain College of Medicine, Al-Nahrain University, Baghdad, Iraq.
Department of Pharmacology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
Open Access Maced J Med Sci. 2019 Jun 12;7(11):1739-1743. doi: 10.3889/oamjms.2019.469. eCollection 2019 Jun 15.
The current study was designed to determine the hepatoprotective effect of well-known drugs. Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4. The antioxidant effects of b-blockers, especially carvedilol, have been described by several investigators. However, for metoprolol, the effect is a bit query as there is only one in-vitro study showing a little hepatoprotective effect. Thus, it is worthy to re-study the hepatoprotective effect of metoprolol.
To explore the possible hepatoprotective effect of Nitroglycerin, N-acetyl cysteine and Metoprolol Tartrate.
The normal serum values of ALP, AST, ALT, TSB and TSP were determined in 35 healthy rabbits allocated to 5 groups before CCL4 induction and at three occasions 24, 72, 120 hrs after induction by CCL4 and treatment with the tested drugs: Nitroglycerin, N-acetyl cysteine and Metoprolol for five successive days.
Showed significant decrease in serum levels of ALP, AST, ALT and TSB with a significant increase in TSP level of all the tested drugs measured at 120 hrs compared with the control and their levels measured at 24, 72 hrs.
All the tested drugs proved in having a hepatoprotective effect when they are given orally to animals. The histopathological sections of the liver tissue supported the real effect of these drugs in the management of ALI.
本研究旨在确定知名药物硝酸甘油、N-乙酰半胱氨酸和美托洛尔在四氯化碳诱导的急性肝损伤中的肝保护作用。几位研究者描述了β受体阻滞剂，尤其是卡维地洛的抗氧化作用。然而，对于美托洛尔，其效果有点存疑，因为仅有一项体外研究显示出轻微的肝保护作用。因此，重新研究美托洛尔的肝保护作用是值得的。
探讨硝酸甘油、N-乙酰半胱氨酸和酒石酸美托洛尔可能的肝保护作用。
将35只健康家兔分为5组，在四氯化碳诱导前以及四氯化碳诱导并用受试药物（硝酸甘油、N-乙酰半胱氨酸和美托洛尔）连续治疗5天后的24、72、120小时这三个时间点，测定碱性磷酸酶（ALP）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、总胆红素（TSB）和总蛋白（TSP）的正常血清值。
与对照组以及在24、72小时测得的水平相比，在120小时测得的所有受试药物的血清ALP、AST、ALT和TSB水平均显著降低，TSP水平显著升高。
所有受试药物经口服给予动物时均被证明具有肝保护作用。肝组织的组织病理学切片支持了这些药物在急性肝损伤治疗中的实际效果。
