Soni Tej P, Soni Sweta, Somani Naresh, Bhattacharya Taruni, Kucha Nilesh
Radiation Oncology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, IND.
Radiation Oncology, All India Institute of Medical Sciences, Jodhpur, IND.
Cureus. 2019 May 14;11(5):e4655. doi: 10.7759/cureus.4655.
Pleural mesothelioma and carcinoma prostate as metachronous double malignancy is extremely rare co-occurrence. A 67-year-old male, diagnosed case of carcinoma prostate with bone metastasis, was treated with chemotherapy and hormone therapy. He responded well to chemotherapy and hormone therapy. He remained asymptomatic for two years with serum prostate-specific antigen (PSA) values within normal limits. After two years of diagnosis of carcinoma prostate, he developed left lung pleural sarcomatoid mesothelioma as a second metachronous tumor. Malignant pleural mesothelioma as a metachronous second tumor in a case of carcinoma prostate is rarely reported in the literature. The long-life expectancy, old age, late effects of the treatment, genetic predisposition and lifestyle factors of patients with carcinoma prostate expose them to the possibility of developing second primary tumor.
胸膜间皮瘤和前列腺癌作为异时性双原发恶性肿瘤极为罕见。一名67岁男性，诊断为前列腺癌伴骨转移，接受了化疗和激素治疗。他对化疗和激素治疗反应良好。他在两年内无症状，血清前列腺特异性抗原（PSA）值在正常范围内。在诊断前列腺癌两年后，他出现了左肺胸膜肉瘤样间皮瘤，作为第二个异时性肿瘤。在前列腺癌病例中，恶性胸膜间皮瘤作为异时性第二个肿瘤在文献中鲜有报道。前列腺癌患者的预期寿命长、年龄大、治疗的晚期效应、遗传易感性和生活方式因素使他们有发生第二原发性肿瘤的可能性。
