Negi Yoshiki, Kuribayashi Kozo, Doi Hiroshi, Funaguchi Norihiko, Koda Yuichi, Fujimoto Eriko, Mikami Koji, Minami Toshiyuki, Yokoi Takashi, Kijima Takashi
Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
Department of Radiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
Mol Clin Oncol. 2018 Aug;9(2):181-186. doi: 10.3892/mco.2018.1650. Epub 2018 Jun 11.
Pleurectomy/decortication (P/D) is the surgical treatment of choice for early malignant mesothelioma, but it remains unclear whether radiotherapy along with P/D should be used as multimodal treatment for this disease. We herein present the case of a 76-year-old man with a history of asbestos exposure who was diagnosed with left-sided malignant pleural mesothelioma in February 2010. The patient underwent chemotherapy with a combination of cisplatin and pemetrexed and achieved stable disease, after which time he was kept under observation. A positron emission tomography/computed tomography scan performed in February 2011 revealed nodular shadows with fluorodeoxyglucose uptake in S3 of the left lung; using bronchoscopy, the patient was diagnosed with stage IIB (cT3N0M0) primary squamous cell carcinoma. Chemoradiotherapy with vinorelbine and 60 Gy/20 fr radiotherapy was performed, and a partial response was obtained, suggesting that the radiotherapy used to treat the carcinoma of the lung may have also helped control the disease activity of the pre-existing mesothelioma. The present case indicates the value of radiotherapy in the treatment of malignant mesothelioma. The aim of the present study was to examine the possibility of new multimodal treatments for mesothelioma, along with a discussion of the relevant literature.
胸膜切除术/纤维板剥脱术（P/D）是早期恶性间皮瘤的首选手术治疗方法，但P/D联合放疗作为该病的多模式治疗是否有效仍不明确。我们在此报告一例76岁有石棉接触史的男性患者，于2010年2月被诊断为左侧恶性胸膜间皮瘤。该患者接受了顺铂和培美曲塞联合化疗并病情稳定，此后接受观察。2011年2月进行的正电子发射断层扫描/计算机断层扫描显示左肺S3有氟脱氧葡萄糖摄取的结节状阴影；通过支气管镜检查，患者被诊断为IIB期（cT3N0M0）原发性鳞状细胞癌。进行了长春瑞滨联合60 Gy/20次分割的放化疗，获得了部分缓解，提示用于治疗肺癌的放疗可能也有助于控制先前存在的间皮瘤的疾病活动。本病例表明放疗在恶性间皮瘤治疗中的价值。本研究的目的是探讨间皮瘤新多模式治疗的可能性，并对相关文献进行讨论。
