溶剂诱导的肽-四硫代噻吩-肽共轭物的超分子组装
Solvent-Induced Supramolecular Assembly of a Peptide-Tetrathiophene-Peptide Conjugate.
作者信息
Guo Zongxia, Wang Yujiao, Zhang Xiao, Gong Ruiying, Mu Youbing, Wan Xiaobo
机构信息
College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, China.
Key Laboratory of Biobased Polymer Materials, Shandong Provincial Education Department, College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, China.
出版信息
Front Chem. 2019 Jun 28;7:467. doi: 10.3389/fchem.2019.00467. eCollection 2019.
The assembly of a peptide-tetrathiophene-peptide (PTP) conjugate has been investigated in mixed solvents, which has different polarities by changing the solvent proportions. It was found that PTP can form fibers in THF/hexane solutions with 40-80%v of hexane. The fibers were stable and did not change on time. On the other hand, PTP formed ordered structures in a mixed solution with the water content from 40 to 60%v. For the as-prepared solutions, two nanostructures vesicles and parallelogram sheets were obtained. The parallelogram sheets could transform into vesicles on time. The fibers showed supramolecular chirality, however, there was no Cotton effect for vesicles and parallelogram sheets. UV-vis, FL, XRD, FT-IR, and CD spectra together with SEM, AFM, TEM were used to characterize the nanostructures and properties of the assemblies. Molecular packing mechanism was proposed based on the experimental data.
已在混合溶剂中研究了肽-四硫代噻吩-肽（PTP）共轭物的组装情况，通过改变溶剂比例，这些混合溶剂具有不同的极性。结果发现，PTP在己烷体积分数为40-80%的四氢呋喃/己烷溶液中能形成纤维。这些纤维很稳定，不会随时间变化。另一方面，PTP在水含量为40至60%（体积分数）的混合溶液中形成有序结构。对于所制备的溶液，获得了两种纳米结构——囊泡和平行四边形片层。平行四边形片层会随时间转变为囊泡。纤维表现出超分子手性，然而，囊泡和平行四边形片层没有科顿效应。利用紫外可见光谱、荧光光谱、X射线衍射、傅里叶变换红外光谱和圆二色光谱以及扫描电子显微镜、原子力显微镜、透射电子显微镜来表征组装体的纳米结构和性质。基于实验数据提出了分子堆积机制。
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